Results 51 to 60 of about 24,051 (299)

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Functional Spermatogenesis Across Testicular Developmental Stages in Neomale Large Yellow Croaker (Larimichthys crocea) Revealed by Histology and Gonadal Specific Cellular Markers

Biology
Gonadal development and spermatogenesis critically influence fish reproductive performance. Neomales (genetically female but functionally male) are indispensable for generating all-female populations, yet their spermatogenesis remains understudied.
Xu Liu, Weihua Hu, Ruiyi Chen, Yang Yang, Sixian Yang, Dongdong Xu   +5 more
doaj   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

Mapping Steroidogenic Perturbations Under Endocrine Disruptor Mixtures Across Demographic Subgroups: Structural and Metabolomic Insights

Advanced Science, EarlyView.
Population‐scale EDC–hormone association mapping among 4255 participants across demographic subgroups identifies phthalate metabolites as the most consistent signals associated with lower testosterone‐related markers in males. Integrative mechanistic validation prioritizes MCPP as a key phthalate metabolite linked to CYP17A1‐centered disruption of ...
Yanling Chen, Lei Huang, Yingtong Jiang, Guohong Zhao, Mengyuan Zhu, Xiulian Lu, Lang Lang, Akinpelumi Oluwatobiloba Esther, Longhao Fan, Yuqi Jiang, Chang Sun, Xiaoling Zhang, Kun Zhou, Xiaoming Ji, Minjian Chen   +14 more
wiley   +1 more source

Relationship between seawater temperature, brain GnRH-like peptide expression, and gonadal development in wild bigfin reef squid (Sepioteuthis lessoniana)

Biological Research
Background Cephalopods are widely distributed in oceans worldwide and are important fishery resources. Most species have a lifespan of approximately one year and die after reproduction.
Umina Kubo, Lee Jaewoo, Ryosuke Murata, Takashi Aoshima, Yuji Mushirobira, Kiyoshi Soyano   +5 more
doaj   +1 more source

POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley   +1 more source

Biochemical Changes during Gonadal Maturation Portunus pelagicus (Linnaeus, 1758) [PDF]

, 2010
The changes in moisture, protein, lipid, carbohydrate and carotenoids in the ovary, hepatopancreas, muscle and haemolymph during the process of gonadal maturation of the crab PorhmllS pelagiclls (Linnaeus, 1758) were nvestigated.
Manisseri, Mary K, Ravi, Raghunath
core  

Biological aspects and population dynamics of Indian mackerel (Rastrelliger kanagurta) in Barru, Makassar Strait, Indonesia

Fisheries and Aquatic Sciences
The present study aims to analyze the biological aspects and population dynamics of Indian mackerel in Barru waters. Data was collected in Barru for 11 months, from June 2022 to April 2023.
Andi Asni, Hasrun, Ihsan, Najamuddin
doaj   +1 more source

Effectiveness of different dosages of vitamin E on the maturation of freshwater lobster (Cherax quadricarinatus)

Acta Aquatica, 2023
This study aims to determine the effectiveness of different doses of vitamin E on the maturation of freshwater crayfish (Cherax quadricarinatus). The method used was a Randomized Block Design (RAK) with 4 treatments and 3 replications.
Mikha Ladio, Siti Komariyah, Andika Putriningtias   +2 more
doaj   +1 more source

The Homozygous p.(Arg215Ter) Variant in XRCC2 Is Associated With Atypical Fanconi Anemia Without Major Hematological Abnormalities in Childhood

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Fanconi Anemia (FA) is the most frequent inherited bone marrow failure syndrome. A role for the XRCC2 gene in FA was suspected in 2012 and confirmed in 2016, but only two affected individuals have been described thus far, and no long‐term follow‐up is available.
Sabina Cenciarelli, Giulia Bruna Marchetti, Maria Iascone, Maria Grazia Patricelli, Sara Giangiobbe, Gabriella Cinzia Pozzobon, Miriam Nella Savini, Fabio Giglio, Alessandro Aiuti, Paola Carrera, Francesca Ferrua, Angela Peron   +11 more
wiley   +1 more source