Results 111 to 120 of about 224,439 (383)

Multi-Task Gaussian Processes and Dilated Convolutional Networks for Reconstruction of Reproductive Hormonal Dynamics [PDF]

arXiv, 2019
We present an end-to-end statistical framework for personalized, accurate, and minimally invasive modeling of female reproductive hormonal patterns. Reconstructing and forecasting the evolution of hormonal dynamics is a challenging task, but a critical one to improve general understanding of the menstrual cycle and personalized detection of potential ...
arxiv  

Reduced model for female endocrine dynamics: Validation and functional variations [PDF]

arXiv, 2020
A normally functioning menstrual cycle requires significant crosstalk between hormones originating in ovarian and brain tissues. Reproductive hormone dysregulation may cause abnormal function and sometimes infertility. The inherent complexity in this endocrine system is a challenge to identifying mechanisms of cycle disruption, particularly given the ...
arxiv  

Leuprorelin‐Induced Thrombocytopenia Successfully Treated With Surgical Resection of the Injection Site

IJU Case Reports, EarlyView.
ABSTRACT Introduction Drug‐induced thrombocytopenia (DITP) can be caused by many kinds of drugs. Its treatment generally involves discontinuation of the responsible drug. Case Presentation A 70‐year‐old man received a subcutaneous injection of long‐acting (24‐week) leuprorelin depot as androgen deprivation therapy for prostate cancer.
Ryota Mori, Satoru Taguchi, Masahiro Yamamoto, Yuta Inoue, Koichiro Kanazawa, Yoichi Fujii, Haesu Lee, Kiichi Furuse, Hiroaki Maki, Jun Kamei, Shigenori Kakutani, Yuta Yamada, Aya Niimi, Daisuke Yamada, Aya Shinozaki‐Ushiku, Tetsuo Ushiku, Mineo Kurokawa, Mutsumi Okazaki, Haruki Kume   +18 more
wiley   +1 more source

A change from gonadotropin releasing hormone antagonist to gonadotropin releasing hormone agonist therapy does not affect the oncological outcomes in hormone sensitive prostate cancer

Basic and Clinical Andrology, 2018
Résumé Contexte L’objectif de notre étude rétrospective était d’évaluer la survie à 5 ans et le délai de transition du cancer de la prostate hormono-sensible au cancer de la prostate résistant à la castration chez des patients porteurs d’un cancer de la ...
Jumpei Asakawa, Taro Iguchi, Satoshi Tamada, Sayaka Yasuda, Noriko Ninomiya, Minoru Kato, Takeshi Yamasaki, Tetusji Ohmachi, Tatsuya Nakatani   +8 more
doaj   +1 more source

Towards Personalized Modeling of the Female Hormonal Cycle: Experiments with Mechanistic Models and Gaussian Processes [PDF]

arXiv, 2017
In this paper, we introduce a novel task for machine learning in healthcare, namely personalized modeling of the female hormonal cycle. The motivation for this work is to model the hormonal cycle and predict its phases in time, both for healthy individuals and for those with disorders of the reproductive system. Because there are individual differences
arxiv  

A unified model for the human response to lipopolysaccharide-induced inflammation [PDF]

arXiv, 2022
This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharide (LPS) injection. The model tracks pro- and anti-inflammatory cytokines (TNF-$\alpha$, IL-6, IL-10), concentrations of corticotropin-releasing hormone (CRH ...
arxiv  

Estrone and estradiol concentrations in human ovaries, testes, and adrenals during the first two years of life [PDF]

, 1987
To determine the origin of estrogens in infant blood, we measured estrone (E1) and estradiol (E2) in the gonads of 50 girls and 64 boys who died suddenly between birth and 2 yr of age as well as in the adrenals of 18 of these infant girls and 16 of the ...
Bidlingmaier, F., Dorr, H. G., Eisenmenger, Wolfgang, Knorr, D., Strom, T. M.   +4 more
core   +1 more source

Molecular Mechanisms of Gonadotropin-Releasing Hormone Signaling: Integrating Cyclic Nucleotides into the Network

Frontiers in Endocrinology, 2013
Gonadotropin-releasing hormone (GnRH) is the primary regulator of mammalian reproductive function in both males and females. It acts via G-protein coupled receptors on gonadotropes to stimulate synthesis and secretion of the gonadotropin hormones ...
R. M. Perrett, C. McArdle
semanticscholar   +1 more source

COLLAB: A Global Survey of Clinical and Laboratory Assessment in Alopecia Areata by Hair Specialists

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Alopecia areata (AA) is a common non‐scarring alopecia. Data continue to emerge on associations with autoimmune and other conditions. Janus kinase inhibitors (JAKi) are increasingly used to treat AA. Objectives The aim was to assess variation in laboratory testing in patients with AA among hair experts internationally and to compare
Cathal O'Connor, Aoife Boyle, Leila Asfour, Bevin Bhoyrul, Laita Bokhari, George Cotsarelis, Chantal Cotter, Brittany Craiglow, Lara Cutlar, Rachita Dhurat, Ncoza Dlova, Isabella Doche, Jeff Donovan, Aaron M. Drucker, Samantha Eisman, Daniel Fernandes Melo, Matthew J. Harries, Maria Hordinsky, Ahmed Kazmi, Brett King, Antonios Kolios, Nekma Meah, Paradi Mirmirani, Arash Mostaghimi, Manabu Ohyama, Yuliya Ovcharenko, Rodrigo Pirmez, Bianca Maria Piraccini, Lidia Rudnicka, David Saceda‐Corralo, Jerry Shapiro, Cathryn Sibbald, Rod Sinclair, Blake R. C. Smith, Michela Starace, Sergio Vaño‐Galván, Wei Liang Koh, Katherine York, Ian McDonald, Dmitri Wall   +39 more
wiley   +1 more source

Generalized-Ensemble Simulations of the Human Parathyroid Hormone Fragment PTH(1-34) [PDF]

, 2003
A generalized-ensemble technique, multicanonical sampling, is used to study the folding of a 34-residue human parathyroid hormone fragment. An all-atom model of the peptide is employed and the protein-solvent interactions are approximated by an implicit solvent. Our results demonstrate that generalized-ensemble simulations are well suited to sample low-
arxiv   +1 more source