Results 171 to 180 of about 111,480 (273)

From “Passive Supplementation” to “Active Repair”: Melatonin Reshapes the Treatment Paradigm for Late‐Onset Hypogonadism by Targeting Leydig Cell Senescence

Aging Cell, Volume 25, Issue 5, May 2026.
Melatonin restores testosterone production in aging Leydig cells by targeting key pathological drivers, particularly oxidative stress and mitochondrial dysfunction. This approach offers a fundamental strategy to reshape the Late‐onset hypogonadism treatment paradigm.
Hui Wu, Gang Ning, Mintao Jian, Ajian Peng, Haoyu Wang, Bonan Li, Xing Zhou   +6 more
wiley   +1 more source

Impact of MED12 mutation and CDK8 activity on uterine leiomyoma growth and response to gonadotropin-releasing hormone agonist treatment. [PDF]

PLoS One
Tanioka S, Asano R, Ota Y, Nagai K, Takenaka K, Mizushima T, Miyagi Y, Miyagi E.   +7 more
europepmc   +1 more source

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Pregnancy outcomes of patients with retained products of conception following miscarriage treated with relugolix, an oral gonadotropin-releasing hormone antagonist. [PDF]

Front Med (Lausanne)
Sasatsu S, Ono Y, Miyashita D, Yoshihara T, Tanaka K, Tada Y, Owada S, Nakagomi A, Ikeda S, Ohgi M, Ogasahara E, Tagaya H, Okuda Y, Yoshino O.   +13 more
europepmc   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, Volume 14, Issue 4, Page 978-991, May 2026.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

A Case of Familial Mediterranean Fever Diagnosed After Oral Administration of a Gonadotropin-Releasing Hormone (GnRH) Antagonist. [PDF]

Cureus
Ueno H, Ohara R, Nakao S, Sasaki J, Satoh T.   +4 more
europepmc   +1 more source

Pharmacogenetics of follicle‐stimulating hormone action in the male

Andrology, Volume 14, Issue 4, Page 1064-1072, May 2026.
Abstract Male factor infertility (MFI) is involved in half of the cases of couple infertility. The follicle‐stimulating hormone (FSH) therapy is considered efficient to improve semen parameters and pregnancy rate in patients with idiopathic MFI, following the lesson learned from hypogonadotropic hypogonadism.
Andrea Graziani, Giuseppe Grande, Raffele Scafa, Riccardo Selice, Andrea Garolla, Maria Santa Rocca, Cinzia Vinanzi, Alberto Ferlin   +7 more
wiley   +1 more source

Cost-effectiveness of dienogest compared to gonadotropin releasing hormone agonists for the management of endometriosis in Vietnam. [PDF]

Cost Eff Resour Alloc
Kieu MTT, Le MH, Nguyen CP.
europepmc   +1 more source

The effect of temporary uterine artery ligation on blood loss during laparoscopic myomectomy: A systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 5, Page 795-804, May 2026.
This meta‐analysis evaluates whether temporary uterine artery ligation (TUAL) reduces intraoperative estimated blood loss during laparoscopic myomectomy (LM). Data from seven comparative studies were analyzed to evaluate their hemostatic efficacy, surgical impact, and suitability for wider clinical use.
Maria M. Witkowiak, Natalie E. Bourdakos, Zoe Y. Zervides, Olga Moutzouri, Marisa M. Dariotis, Liranne Bitton, Fatma A. M. Abdulsalam, Hayato Nakanishi, Christian A. Than, Anna Abacjew‐Chmylko   +9 more
wiley   +1 more source

Oral Gonadotropin-Releasing Hormone Antagonists in the Treatment of Endometriosis: Advances in Research. [PDF]

J Clin Med Res
Wang JY, Zhang Y, Ding J.
europepmc   +1 more source