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Fertility Preservation and Ovarian Hyperstimulation Syndrome Management in Cancer Care: A Pathophysiological Perspective on Gonadotropin-Releasing Hormone Agonists and Antagonists. [PDF]
PathophysiologyBedoschi G, Ingold C, Navarro PA.
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Gonadotropin-releasing hormone
Trends in Endocrinology & MetabolismMiguel Ruiz-Cruz +2 more
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Evolution of gonadotropin-releasing hormones [PDF]
Trends in Endocrinology & Metabolism, 1992 GnRH was originally isolated as a hypothalamic peptide hormone that regulates the reproductive system by stimulating the release of gonadotropins from the anterior pituitary. However, multiple molecular forms of the peptide have evolved, which have been coopted for a variety of regulatory functions: as a neurotransmitter in the central and sympathetic ...
Robert P. Millar, Judy A. King
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Gonadotropin-releasing hormone/gonadotropin-releasing hormone receptor signaling in the placenta
Current Opinion in Endocrinology, Diabetes & Obesity, 2011This review summarizes our current understanding of the role of gonadotropin-releasing hormone (GnRH)/GnRH receptor (GnRHR) signaling at the maternal-fetal interface.Several isoforms of GnRH and GnRHR are described. The hypothalamic decapeptide, GnRH-I, binds to the anterior pituitary and induces the synthesis and secretion of luteinizing hormone and ...
Errol R. Norwitz, Kirsten Sasaki
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Gonadotropin-Releasing Hormone in the Ovary
Reproductive Sciences, 2007Gonadotropin-releasing hormone (GnRH) plays a pivotal role in the physiology of reproduction in mammals. GnRH acts by binding to the GnRH receptor (GnRHR). In humans, only 1 conventional GnRH receptor subtype (type I GnRH receptor) has been found. In the human genome, 2 forms of GnRH have been identified, GnRH-I (mammal GnRH) and GnRH-II (chicken GnRH ...
Chryssa Metallinou +3 more
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Gonadotropin-releasing hormone deficiency in men: Diagnosis and treatment with exogenous gonadotropin-releasing hormone [PDF]
American Journal of Obstetrics and Gynecology, 1990 Idiopathic hypogonadotropic hypogonadism in men is the result of absent or abnormal secretion of gonadotropin-releasing hormone, which prevents pubertal development. Isolated gonadotropin-releasing hormone deficiency is clinically and neuroendocrinologically heterogeneous, largely because of variation in the degree of gonadotropin-releasing hormone ...
William F. Crowley, R W Whitcomb
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Gonadotropin-Releasing Hormone
Annual Review of Medicine, 1975The existence of a hypothalamic gonadotropin-releasing hormone long suspected from indirect evidence (1) has now been conclusively proven. In 1971, the primary structure of porcine (2) and subsequently ovine (3) luteinizing hormone-releasing hormone or factor (LRH or LRF) was determined to be the decapeptide pGlu-His Trp-Ser-Tyr-Gly-Leu-Arg-pro-Gly ...
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