Results 51 to 60 of about 311,390 (296)

Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men [PDF]

, 2016
Context: A subpopulation of hypothalamic neurons co-localise three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis);
Abbara, A, Bassett, P, Bloom, S, COMNINOS, A, Dhillo, WS, Jayasena, C, Mizamtsidi, M, Narayanaswamy, S, Papadopoulou, D, Prague, J, Shah, A, Veldhuis, J   +11 more
core   +1 more source

Growth and descent of the testes in infants with hypogonadotropic hypogonadism receiving subcutaneous gonadotropin infusion

International Journal of Pediatric Endocrinology, 2016
BackgroundOne third of infants with congenital hypogonadotropic hypogonadism (CHH) are said to have micropenis and/or bilateral or unilateral cryptorchidism leading many of them to orchiopexy.
A. Lambert, P. Bougnères
semanticscholar   +1 more source

Live Birth in Woman With Premature Ovarian Insufficiency Receiving Ovarian Administration of Platelet-Rich Plasma (PRP) in Combination With Gonadotropin: A Case Report

Frontiers in Endocrinology, 2020
The conception rates among women with premature ovarian insufficiency (POI) remain extremely low. To achieve a successful pregnancy, most of these women have to receive donor oocytes through IVF treatment.
Chao-Chin Hsu, Chao-Chin Hsu, Leonard Hsu, Isabel Hsu, Yi-Jen Chiu, Sonam Dorjee   +5 more
doaj   +1 more source

Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty

Journal of Neuroscience, 2005
We examined the role of kisspeptin and its receptor, the G-protein-coupled receptor GPR54, in governing the onset of puberty in the mouse. In the adult male and female mouse, kisspeptin (10–100 nm) evoked a remarkably potent, long-lasting depolarization ...
S. Han, M. L. Gottsch, Kathy J Lee, S. Popa, Jeremy T. Smith, Sonya K. Jakawich, D. Clifton, R. Steiner, A. Herbison   +8 more
semanticscholar   +1 more source

Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. [PDF]

, 2017
BackgroundProper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development, leading to ...
Brayman, Melissa J, Hoffmann, Hanne M, Iyer, Anita K, Mellon, Pamela L, Ngo, Cindy, Sunshine, Mary Jean, Xie, Huimin   +6 more
core   +3 more sources

Role of pituitary adenylate cyclase‐activating polypeptide in modulating hypothalamic‐pituitary system

Reproductive Medicine and Biology, 2018
Background Pituitary adenylate cyclase‐activating polypeptide (PACAP) is a multifunctional peptide that is isolated and identified from the ovine hypothalamus, whose effects and mechanisms have been elucidated in numerous studies.
Aki Oride, Haruhiko Kanasaki, Satoru Kyo
doaj   +1 more source

Pubertal Development in Girls with Beta Thalassaemia and Assessment of the Adequacy of Chelation Therapy: A Quasi-experimental Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Beta thalassaemia is the most prevalent hereditary autosomal disorder, significantly impacting endocrine function during pubertal development. The pathology is rooted in the excessive deposition of iron in vital organs.
Rupali Modak, Amitava Pal, Shuvendu Das, Dilip Kumar Biswas   +3 more
doaj   +1 more source

Gonadotropin and kisspeptin gene expression, but not GnRH, are impaired in cFOS deficient mice. [PDF]

, 2015
cFOS is a pleiotropic transcription factor, which binds to the AP1 site in the promoter of target genes. In the pituitary gonadotropes, cFOS mediates induction of FSHβ and GnRH receptor genes.
Coss, Djurdjica, Jonak, Carrie R, Kauffman, Alexander S, Xie, Changchuan   +3 more
core   +1 more source

The Role of RFamide-Related Peptide-3 in Age-Related Reproductive Decline in Female Rats. [PDF]

, 2016
Reproductive senescence, the point in time when females cease to show estrous cyclicity, is associated with endocrine changes in the hypothalamus, pituitary, and gonads. However, the mechanisms triggering this transition are not well understood.
Bentley, George E, Geraghty, Anna C, Kaufer, Daniela, Kriegsfeld, Lance J, Muroy, Sandra E   +4 more
core   +1 more source

Prognostic factors in seminomas with special respect to HCG: Results of a prospective multicenter study [PDF]

, 1999
Objective: In a prospective multicenter trial, it was our intention to elucidate clinical prognostic factors of seminomas with special reference to the importance of human chorionic gonadotropin (HCG) elevations in histologically pure seminomas. Methods:
Bussar-Maatz, R., Dieckmann, K. P., Fassbinder, J., Hartmann, M., Löhrs, U., Mann, K., Schubert, G. E., Weissbach, L.   +7 more
core   +1 more source