Results 51 to 60 of about 129,538 (260)

Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. [PDF]

, 2017
BackgroundProper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development, leading to ...
Brayman, Melissa J, Hoffmann, Hanne M, Iyer, Anita K, Mellon, Pamela L, Ngo, Cindy, Sunshine, Mary Jean, Xie, Huimin   +6 more
core   +3 more sources

Nociceptive Nerve‐Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b+ CD146+ Fibroblast Differentiation

Advanced Science, EarlyView.
This study investigates adenomyosis fibrosis in relation to nociceptive nerves. Nociceptive nerve‐secreted CGRP promotes RAMP1hi CD140b+ CD146+ fibroblast differentiation into myofibroblasts through ERK activation, causing severe fibrosis. Rimegepant‐induced CGRP/RAMP1 signaling blockade alleviates fibrosis and restores fertility in a mouse model. This
Zi Ye, Anning Zhao, Xia Li, Yanqing Hao, Dong Huang, Jianmin Chen, Tiantian Li, Yangyang Dai, Wenchao Sun, Lie Ma, Songying Zhang, Liaobing Xin   +11 more
wiley   +1 more source

From patient classification to optimized treatment in ART: the AMPLITUDE Delphi consensus

Frontiers in Reproductive Health
IntroductionA Delphi consensus was performed to evaluate expert opinions on the management of key aspects of ovarian stimulation.MethodsA Scientific Committee developed eleven statements for patient profiles corresponding to predicted ovarian responses ...
Christophe Blockeel, Anne Guivarc’h-Leveque, Catherine Rongieres, Nelly Swierkowski-Blanchard, Nelly Swierkowski-Blanchard, Géraldine Porcu-Buisson, Chadi Yazbeck, Chadi Yazbeck, Christine Wyns   +8 more
doaj   +1 more source

Keterlambatan Pubertas

Sari Pediatri, 2016
Keterlambatan pubertas merupakan masalah penting pada anak karena dapat terjadi keterlambatan pertumbuhan dan maturasi tulang. Diagnosis keterlambatan pubertas ditegakkan berdasarkan anamnesis, pemeriksaan fisik, laboratorium dan radiologi.
Syamsul Azwar
doaj   +1 more source

Expression of three GnRH receptors in specific tissues in male and female sea lampreys Petromyzon marinus at three distinct life stages [PDF]

, 2013
Two recently cloned gonadotropin-releasing hormone (GnRH) receptors (lamprey GnRH-R-2 and lamprey GnRH-R-3) along with lamprey (l) GnRH-R-1 were shown to share similar structural features and amino acid motifs common to other vertebrate receptors.
Daukss, Dana M., Decatur, Wayne A., Hall, Jeffrey A., Hayes, Mary K.   +3 more
core   +1 more source

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

Advanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song, Zhaoqing Guan, Guiyi Ji, Jing Wang, Xiurui Yan, Yujie Zhang, Yinliang Zhang, Chunfang Ha, Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan   +11 more
wiley   +1 more source

FSH receptor N680S genotype-guided gonadotropin choice increases cumulative pregnancy and live birth rates after in vitro fertilization

Frontiers in Endocrinology
ObjectiveThis study aimed to compare cumulative [fresh and frozen embryo transfers from one ovarian stimulation (OS) cycle] pregnancy and live birth rates in women for whom the choice between recombinant FSH (rFSH) and urinary FSH (uFSH) for OS was ...
Ida Hjelmér, Mathilda Nilsson, Emir Henic, Emir Henic, Piotr Jędrzejczak, Hannah Nenonen, Katarzyna Ozegowska, Aleksander Giwercman, Aleksander Giwercman, Margareta Laczna Kitlinski, Yvonne Lundberg Giwercman   +10 more
doaj   +1 more source

Identification of key miRNAs as regulatory biomarkers of gonadotropins leading to infertility in males

Акушерство, гинекология и репродукция, 2023
Introduction. Infertility is a highly fatal reproductive system disorder that affects the ability of a couple to reproduce. Over the past decades, a drastic uplift has been recorded in infertility cases among males ranging from 20 to 70 % indicating ...
N. A. Oohayyed, M. M. Mohammed, A. M. Al-Rahim, R. N. Al Chalabi, S. A. Shaban, A. A. J. Suleiman   +5 more
doaj   +1 more source

Update on male reproductive endocrinology. [PDF]

, 2018
Practitioners of male reproductive and sexual medicine must have an intimate understanding of the physiology of male reproductive endocrinology, as such a knowledge is the cornerstone on which hormonal treatments are based.
Clavijo, Raul, Hsiao, Wayland
core   +1 more source

Species-specific differences in follicular antral sizes result from diffusion-based limitations on the thickness of the granulosa cell layer

, 2013
The size of mature oocytes is similar across mammalian species, yet the size of ovarian follicles increases with species size, with some ovarian follicles reaching diameters more than 1000-fold the size of the enclosed oocyte.
Bächler, M., De Geyter, Ch., Iber, D., Menshykau, D.   +3 more
core   +1 more source