Results 61 to 70 of about 129,538 (260)

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

open access: yesAdvanced Science, EarlyView.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang   +9 more
wiley   +1 more source

Prevalence of Elevated Luteinizing Hormone (LH)/Follicle Stimulating Hormone (FSH) Ratio in Polycystic Ovary Syndrome (PCOS) Women Among Local Population

open access: yesJournal of the Dow University of Health Sciences, 2011
Objective: To assess the frequency of elevated LH/FSH ratio>1 in women with polycystic ovary syndromeamong local population.Study Design: Cross-sectional study.
Shehla Haider   +3 more
doaj   +2 more sources

Laeverin is Cell‐Surface Target for Liquid‐Phase Metastasizing Cancer Cells

open access: yesAdvanced Science, EarlyView.
This study revealed that epithelial cancer cells in the floating phase induce the expression of laeverin (LVRN) that is a trophoblast‐specific and cell‐surface immunoregulatory factor and showed that anti‐LVRN ADC is a promising agent that can attack cancer cells in the metastatic liquid phase and block further distant metastasis.
Haruki Kasama   +17 more
wiley   +1 more source

Regulation of MMP2 and MMP9 metalloproteinases by FSH and growth factors in bovine granulosa cells

open access: yesGenetics and Molecular Biology, 2009
Matrix metalloproteinases (MMP) are key enzymes involved in tissue remodeling. Within the ovary, they are believed to play a major role in ovulation, and have been linked to follicle atresia.
Valerio M. Portela   +2 more
doaj  

Roles of Gonadotropin Receptors in Sexual Development of Medaka

open access: yesCells, 2022
The gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), are secreted from the pituitary and bind to the FSH receptor (FSHR) and LH receptor (LHR) to regulate gonadal development in vertebrates. Previously, using fshr-knockout (
Takeshi Kitano   +7 more
doaj   +1 more source

Estrous behavior in dairy cows: identification of underlying mechanisms and gene functions [PDF]

open access: yes, 2010
Selection in dairy cattle for a higher milk yield has coincided with declined fertility. One of the factors is reduced expression of estrous behavior. Changes in systems that regulate the estrous behavior could be manifested by altered gene expression ...
Beerda, B.   +3 more
core   +2 more sources

TBX3‐ Related Disorder

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous pathogenic variants in TBX3 cause Ulnar‐Mammary syndrome (UMS). The phenotype is classically characterized by upper limb defects, apocrine/mammary gland hypoplasia, hypogonadism, and various midline defects. However, the clinical spectrum is highly variable, and some individuals may present with a mild or atypical presentation ...
Ziv Halperin, Karin Weiss
wiley   +1 more source

PACAP induces FSHβ gene expression via EPAC. [PDF]

open access: yes, 2019
Gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are heterodimers of a common α subunit and unique β subunits. Regulation of their levels, primarily by GnRH, is critical for reproductive function.
Coss, Djurdjica, Yeh, Debra M
core  

A meta-analysis and systematic review of randomized controlled trials with degarelix versus gonadotropin-releasing hormone agonists for advanced prostate cancer [PDF]

open access: yes, 2016
Our aim was to systematically evaluate the benefits of degarelix as antagonist versus agonists of gonadotropin-releasing hormones (GnRH) for the treatment of advanced prostate cancer (PC).
CATTARINO, SUSANNA   +10 more
core   +1 more source

A Systematic Review and Meta‐Analysis of the Birth Prevalence of Turner Syndrome

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Turner syndrome, a chromosomal disorder, causes short stature, pubertal arrest, amenorrhea, and infertility in females. Prevalence estimates vary widely; however, reliable estimates are important for public health initiatives. Therefore, a meta‐analysis was undertaken.
David Hinds   +5 more
wiley   +1 more source

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