Results 111 to 120 of about 27,853 (255)

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

Gonadotropins Across the Lifespan: Their role in the Neurodevelopment-Neurodegeneration Continuum. [PDF]

Yale J Biol Med
Galbraith JA, Elhassan MZ, Rocha JF, Al Mozani TA, Fredericks CA.   +4 more
europepmc   +1 more source

Cyclooxygenase-2 is an essential mediator of gonadotropins-induced apoptosis of human ovarian surface epithelial cells

, 2006
Objective: To investigate the signaling mechanism underlying gonadotropins-mediated apoptosis of human ovarian surface epithelial (OSE) cells. Methods: OSE cells were treated with surge concentrations of gonadotropins (FSH and LH/hCG), membrane ...
Pon, YL, Wong, AST
core  

Parallel Liquid Biopsy Analysis of miR‐371a‐3p and Cell‐Free DNA in an Unselected Cohort of Patients With Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background Despite robust data showing strong potential to improve diagnosis and disease monitoring in testicular germ cell tumors (TGCTs), miR‐371a‐3p testing has not yet been implemented in routine clinical practice. Cell‐free DNA (cfDNA) represents another promising liquid biopsy biomarker that may provide complementary molecular ...
Laura Matouskova, Romy Kralova, Eva Parobkova, Violeta Bakardjieva‐Mihaylova, Martina Zwyrtkova, Karolina Skvarova Kramarzova, Ludmila Boublikova   +6 more
wiley   +1 more source

Luteinizing hormone activity in ovarian stimulation: comparative efficacy and safety of gonadotropins <i>versus</i> recombinant follicle-stimulating hormone-a systematic review and meta-analysis. [PDF]

Front Endocrinol (Lausanne)
Espinós JJ, Checa MA, Villegas-Arbelaez E, Martínez-Zapata MJ.   +3 more
europepmc   +1 more source

Intrauterine Growth and Male Reproductive Health: A Follow‐up Study From the Danish National Birth Cohort

Andrology, EarlyView.
ABSTRACT Background Reduced intrauterine growth might affect male reproductive health later in life, however, existing research remain inconclusive. Objectives To investigate the association between placental weight and birthweight Z‐scores and semen characteristics, testes volume, and reproductive hormone levels in young men.
Anne Gaml‐Sørensen, Nis Brix, Andreas Ernst, Sandra Søgaard Tøttenborg, Mette Møller Dornfeldt, Karin Sørig Hougaard, Siri Eldevik Håberg, Mikko Myrskylä, Gunnar Toft, Jens Peter Ellekilde Bonde, Cecilia Høst Ramlau‐Hansen   +10 more
wiley   +1 more source

Machine Learning‐Based Prediction of Sperm Retrieval Outcomes in Patients With Klinefelter Syndrome: A Multicenter Study With External Validation

Andrology, EarlyView.
ABSTRACT Background The Klinefelter syndrome is a common genetic cause of male infertility, and testicular sperm extraction (TESE) enables sperm retrieval in a subset of affected patients. However, predicting TESE success remains challenging due to the heterogeneous clinical and endocrinological presentation of the Klinefelter syndrome.
Murat Gül, Ali Şahin, Cevahir Özer, Mesut Altan, Tansu Güdelci, Kadir Can Sahin, Mehmet Hamza Gültekin, Muhammed Arif İbis, Mesut Berkan Duran, Burak Sivaslıoğlu, Eray Hasırcı, Mert Kılıç, Ali Can Albaz, Gökhan Çeker, Gianmaria Salvio   +14 more
wiley   +1 more source

Advances in the Use of Recombinant Gonadotropins for Reproductive Biotechnologies in Ruminants: A Review. [PDF]

Reprod Domest Anim
Di Domenico VL, de Moraes FP, de Castro NÁ, de Oliveira FC, Magnabosco D, Gasperin BG.   +5 more
europepmc   +1 more source

The Bidirectional Association Between MASLD and Male Hypogonadism: An Updated Meta‐Analysis

Andrology, EarlyView.
ABSTRACT Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) and male hypogonadism are increasingly prevalent, metabolically interrelated conditions. Testosterone (T) deficiency has been implicated in hepatic lipid dysregulation, insulin resistance, and visceral adiposity, whereas MASLD may impair the hypothalamic–pituitary ...
Giorgia Spaggiari, Leonardo Dalla Valentina, Cristina Felicani, Filippo Gabrielli, Simonetta Lugari, Giovanni Corona, Paolo Ventura, Manuela Simoni, Fabio Nascimbeni, Daniele Santi   +9 more
wiley   +1 more source

LHCGR phamacodynamic effects during follicular maturation. [PDF]

Front Endocrinol (Lausanne)
Perri C, Casarini L, Lazzaretti C.
europepmc   +1 more source