Results 151 to 160 of about 30,100 (305)

Cryopreservation of Spermatozoa Prior and Post‐Orchiectomy in Patients With Testicular Germ Cell Cancer—Does the Timing Matter?

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell cancer (TGCC) is the most frequent malignancy in young men of reproductive age. According to guidelines, semen cryopreservation should be performed prior to orchiectomy. Lack of time and local facilities as well as mental pressure are challenges in terms of fertility preservation before surgery.
Yuhe Tang, Gerald Pühse, Sabine Kliesch, Jann‐Frederik Cremers, Maria Schubert   +4 more
wiley   +1 more source

Cloning and co-expression 3 subunits of human gonadotropins ( FSH, LH) [PDF]

, 2016
Background: Human gonadotropins including LH, FSH, and HCG those secreted from ‎anterior pituitary which has an important role in the reproductive system, and belong to glycoprotein hormone families with heterodimeric ‎structure.
Tavasoli, Afsaneh, Bandehpour, Mojgan, Gheibi, Nematollah, Kazemi, Bahram, Piri, Hossein   +4 more
core  

A Unified Machine Learning Model for Relapse Prediction in Clinical Stage I Testicular Cancer

Andrology, EarlyView.
ABSTRACT Background Approximately one‐fourth of patients with clinical stage I testicular cancer relapse. For decades, risk stratification has been based on different tumor characteristics for seminomas and non‐seminomas. Previous studies primarily used Cox proportional‐hazards models and included only a limited number of variables.
Thomas Wagner, Ramtin Zargari Marandi, Jakob Lauritsen, Daniel Dawson Murray, Mikkel Bandak, Birgitte Grønkær Toft, Dan Berney, Gedske Daugaard   +7 more
wiley   +1 more source

In Situ Expression of miR‐371a‐3p and miR‐373‐3p in Testicular Germ Cell Tumours and Detection in Serum

Andrology, EarlyView.
ABSTRACT Background Testicular germ cell tumours (TGCTs) are the most common type of tumour diagnosed in young men, and reliable non‐invasive biomarkers are crucial for clinical management. MicroRNAs (miRNAs) from the miR‐371–373 cluster have recently been identified as novel and more sensitive serum biomarkers than the conventional protein‐based ...
Nina Mørup, Merve Tatli, Thomas Wagner, Helle Margit Albrechtsen, Gülizar Saritas, Gedske Daugaard, Sofia B. Winge, Kristian Almstrup   +7 more
wiley   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Association Between FTO rs1558902 Polymorphism, Age‐Related Hypogonadism, and Central Obesity in Japanese Men

Andrology, EarlyView.
ABSTRACT Background Obesity and low testosterone levels are closely interconnected, with the FTO gene being the most robust genetic determinant of body mass index (BMI). However, whether this primary genetic driver of obesity directly influences the hypothalamic‐pituitary‐testicular (HPT) axis remains unclear.
Takahiro Tsutsumi, Hideyuki Okuma, Fuminori Kazama, Masumi Endo, Yuna Takato, Hitomi Nara, Asako Miyazaki, Nozomi Harai, Kyoichiro Tsuchiya   +8 more
wiley   +1 more source

Loss‐of‐Function Variants in CCDC189 Cause Human Oligoasthenoteratozoospermia by Disrupting Sperm Flagellar and Acrosomal Architecture

Andrology, EarlyView.
ABSTRACT Background Oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count, impaired motility, and abnormal morphology, is a major cause of male infertility with substantial genetic heterogeneity. However, the underlying genetic etiology remains unresolved in a large proportion of affected individuals.
Jianteng Zhou, Ghulam Mustafa, Tingting Lin, Jingwei Ye, Huan Zhang, Hanwei Jiang, Kexin Yang, Guoning Huang, Qinghua Shi   +8 more
wiley   +1 more source

Parallel Liquid Biopsy Analysis of miR‐371a‐3p and Cell‐Free DNA in an Unselected Cohort of Patients With Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background Despite robust data showing strong potential to improve diagnosis and disease monitoring in testicular germ cell tumors (TGCTs), miR‐371a‐3p testing has not yet been implemented in routine clinical practice. Cell‐free DNA (cfDNA) represents another promising liquid biopsy biomarker that may provide complementary molecular ...
Laura Matouskova, Romy Kralova, Eva Parobkova, Violeta Bakardjieva‐Mihaylova, Martina Zwyrtkova, Karolina Skvarova Kramarzova, Ludmila Boublikova   +6 more
wiley   +1 more source

Intrauterine Growth and Male Reproductive Health: A Follow‐up Study From the Danish National Birth Cohort

Andrology, EarlyView.
ABSTRACT Background Reduced intrauterine growth might affect male reproductive health later in life, however, existing research remain inconclusive. Objectives To investigate the association between placental weight and birthweight Z‐scores and semen characteristics, testes volume, and reproductive hormone levels in young men.
Anne Gaml‐Sørensen, Nis Brix, Andreas Ernst, Sandra Søgaard Tøttenborg, Mette Møller Dornfeldt, Karin Sørig Hougaard, Siri Eldevik Håberg, Mikko Myrskylä, Gunnar Toft, Jens Peter Ellekilde Bonde, Cecilia Høst Ramlau‐Hansen   +10 more
wiley   +1 more source

Machine Learning‐Based Prediction of Sperm Retrieval Outcomes in Patients With Klinefelter Syndrome: A Multicenter Study With External Validation

Andrology, EarlyView.
ABSTRACT Background The Klinefelter syndrome is a common genetic cause of male infertility, and testicular sperm extraction (TESE) enables sperm retrieval in a subset of affected patients. However, predicting TESE success remains challenging due to the heterogeneous clinical and endocrinological presentation of the Klinefelter syndrome.
Murat Gül, Ali Şahin, Cevahir Özer, Mesut Altan, Tansu Güdelci, Kadir Can Sahin, Mehmet Hamza Gültekin, Muhammed Arif İbis, Mesut Berkan Duran, Burak Sivaslıoğlu, Eray Hasırcı, Mert Kılıç, Ali Can Albaz, Gökhan Çeker, Gianmaria Salvio   +14 more
wiley   +1 more source