Results 31 to 40 of about 42,558 (309)

Testicular dysfunction at diagnosis in children and teenagers with haematopoietic malignancies improves after initial chemotherapy

Frontiers in Endocrinology, 2023
IntroductionHematopoietic malignancies are the most frequent type of cancer in childhood. Recent advances in cancer treatment have significantly improved survival until adulthood. There is an extensive literature on the effects of cancer treatment on the
Jimena Lopez Dacal, Silvina Prada, Lourdes Correa Brito, Maria Gabriela Ropelato, Maria Gabriela Ballerini, Maria Eugenia Rodriguez, Marcela E. Gutiérrez, Marcela Soria, Lorena Morán, Cristina Ferraro, Patricia Bedecarrás, Guillermo Drelichman, Luis Aversa, Ignacio Bergadá, Rodolfo A. Rey, Romina P. Grinspon   +15 more
doaj   +1 more source

Transcriptome analysis reveals effects of ethynylestradiol and bisphenol A on multiple endocrine and metabolic pathways in the pituitary and liver of female Atlantic cod (Gadus morhua)

Frontiers in Endocrinology
IntroductionThe pituitary and liver are among the main sites of action of estrogens in fish. Years of research has shown that xenoestrogens can interfere with functions of estrogens. There is however incomplete understanding of xenoestrogen targets genes,
Fekadu Yadetie, Xiaokang Zhang, Anna Reboa, Gwenaëlle Samantha Chloe Noally, Mariann Eilertsen, Mitchell Stewart Fleming, Jon Vidar Helvik, Inge Jonassen, Anders Goksøyr, Odd André Karlsen   +9 more
doaj   +1 more source

Pulsatile gonadotropin-releasing hormone: clinical applications of a physiologic paradigmEssential Points

F&S Reports, 2023
Gonadotropin-releasing hormone (GnRH) is a fundamental driver of human reproduction. A pulsatile pattern of GnRH secretion is essential to achieve pituitary stimulation, gonadotropin secretion, and normal gonadal function.
Marco Filicori, M.D.
doaj   +1 more source

Impact of 6-month triptorelin formulation on predicted adult height and basal gonadotropin levels in patients with central precocious puberty

Frontiers in Endocrinology, 2023
BackgroundTriptorelin, a long-acting gonadotropin-releasing hormone (GnRH) agonist, is available in 1-, 3-, and 6-month formulations to treat central precocious puberty (CPP).
Eunjoo Yoo, Sinae Kim, Hye Lim Jung, Jung Yeon Shim, Jae Won Shim, Deok Soo Kim, Ji Hee Kwak, Eun Sil Kim, Aram Yang   +8 more
doaj   +1 more source

Endocrine and metabolic evaluation of classic Klinefelter syndrome and high-grade aneuploidies of sexual chromosomes with male phenotype: are they different clinical conditions? [PDF]

, 2018
Klinefelter syndrome (KS) is the most common sex chromosome aneuploidy in males. As well as classic KS, less frequent higher-grade aneuploidies (HGAs) are also possible.
Anzuini, Antonella, Granato, Simona, Lenzi, Andrea, Mileno, Benedetta, Radicioni, Antonio F, Rossi, Fabio, Spaziani, Matteo, Tahani, Natascia   +7 more
core   +1 more source

The effects of flutamide on the neonatal rat hypothalamic–pituitary–adrenal and gonadal axes in response to hypoxia

Physiological Reports, 2019
Hypoxia is common with preterm birth and may lead to long‐term effects on the adult hypothalamic–pituitary–adrenal (HPA) axis that are sexually dimorphic due to neonatal androgens.
Santiago Rolon, Christine Huynh, Maya Guenther, Minhal Gardezi, Jonathan Phillips, Ashley L. Gehrand, Hershel Raff   +6 more
doaj   +1 more source

Hormone Receptor Site Maturation in the Secondary Sex Organs of Immature Male and Female Rats [PDF]

, 1976
The effect of a combined dose of pregnant mares\u27 serum (PAAS) and human chor ionic gonadotropin (HCG) on male and female rats 2-25 days old was studied. Groups of animals were given injections for three days, then sacrificed on the fourth day.
Thomas, K. J.
core   +2 more sources

Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 Oxidoreductase deficiency [PDF]

, 2010
Context: P450 oxidoreductase (POR) is a crucial electron donor to all microsomal P450 cytochrome (CYP) enzymes including 17α-hydroxylase (CYP17A1), 21-hydroxylase (CYP21A2) and P450 aromatase.
Adachi, Antley, Arlt, Auchus, Belgorosky, Birgit Köhler, Bulun, Byskov, Cedric H. L. Shackleton, Dharia, Dhir, Dominique Maiter, Ewa M. Malunowicz, Falhammar, Felicity Collins, Flück, Fujieda, Fukami, Fukami, Fukami, Grondahl, Grøndahl, Hague, Huang, Huang, Idkowiak, Jan Idkowiak, Jin, Krone, Latronico, Luitgard Margarete Graul-Neumann, Mallin, Mann, Maria Szarras-Czapnik, Martin Silink, Mehul Dattani, Michiel N. Kerstens, Mullis, New, Nguyen, Nicole Reisch, Nils Krone, Otto, Ribes, Rosa, Roux, Rozman, Sahakitrungruang, Schmidt, Shackleton, Shima, Stephen O'Riordan, Suzuki, Tanae, ten Kate-Booij, Tomalik-Scharte, Wang, Wang, Wiebke Arlt, Wilson   +59 more
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Species-specific differences in follicular antral sizes result from diffusion-based limitations on the thickness of the granulosa cell layer

, 2013
The size of mature oocytes is similar across mammalian species, yet the size of ovarian follicles increases with species size, with some ovarian follicles reaching diameters more than 1000-fold the size of the enclosed oocyte.
Bächler, M., De Geyter, Ch., Iber, D., Menshykau, D.   +3 more
core   +1 more source