Results 181 to 190 of about 41,941 (247)

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Physiological Mechanisms and Life History Trade-Offs in Salmonids Shape In-Tissue Correlations of an Essential Micronutrient. [PDF]

Ecol Evol
Ejsmond MJ, Todisco V, Hauber MM, Hindar K, Hylander S.   +4 more
europepmc   +1 more source

Weaponry Investment in the Socially Monogamous Snapping Shrimp Alpheus brasileiro (Decapoda: Alpheidae)

Acta Zoologica, EarlyView.
ABSTRACT Weapons are morphological structures used by animals in various contexts, especially in intra‐specific contests and visual displays. In snapping shrimps of the genus Alpheus, particularly the monogamous species Alpheus brasileiro, both sexes bear enlarged chelipeds, potentially conferring advantages in mate competition or territorial defence ...
Leonardo Moreira, Caio Santos Nogueira, Régis Augusto Pescinelli, Rogerio Caetano Costa   +3 more
wiley   +1 more source

Evolutionary constraints on anuran melanin for 45 million years. [PDF]

iScience
Falk D, Quigley A, Carazo Del Hoyo B, Rossi V, Webb SM, Wings O, McNamara ME.   +6 more
europepmc   +1 more source

Changes in sleep patterns in adolescents are more associated with pubertal indicators than age: A perfect storm with a dash of hormones

British Journal of Developmental Psychology, EarlyView.
Abstract As they become older, adolescents tend to prefer sleeping and rising later. Yet, it is still unclear if these sleep changes occur due to advancing age or because adolescents are more pubertally mature. This was investigated cross‐sectionally in a sample of 121 Brazilian 9‐to‐17‐year‐olds.
Yessica Alejandra Martínez‐Sánchez, Debora Cristina Hipolide, Rafaella Sales de Freitas, Sabine Pompeia   +3 more
wiley   +1 more source

Overexpression of SOX3 due to an X chromosome inversion leading to ovotesticular difference in sex development. [PDF]

Biol Sex Differ
Nascimento-Vidoti CG, Fabbri-Scallet H, Guaragna MS, de Wallau MB, de Souza VS, da Costa SS, Krepischi ACV, Mazzeu JF, Carvalho CMB, Maciel-Guerra AT, Guerra-Júnior G, Vieira TP.   +11 more
europepmc   +1 more source

Molecular characterization and expression analysis of GATA1 in the blood clam Anadara granosa reveals its role in gonadal development. [PDF]

BMC Genomics
Xu Y, Zhang C, Zhang L, Wang J, Liu H, Bao Y.   +5 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Mixed Gonadal Dysgenesis: A Comprehensive Review of Clinical Spectrum, Diagnostic Strategies, and Management Approaches. [PDF]

Clin Endocrinol (Oxf)
Giri D, Yewale S, Hickingbotham H, Williams C, Shalaby M, Alderson J, Park J.   +6 more
europepmc   +1 more source

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

British Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils‐Bonnet, Martin Wabitsch, Margaret R. MacLean   +12 more
wiley   +1 more source