Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Lessons learnt from implementing the Good Governance for Medicines Programme in Zimbabwe. [PDF]
BMJ Glob Health, 2022 Maponga CC +10 more
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
A Volatile Context: A Revisionist Lens on Good Governance. [PDF]
Development (Rome), 2021 Zuber R.
europepmc +1 more source
Pelaksanaan Good Governance pada Program Grand Strategi dalam Mewujudkan Kota Transit dan Petropolitan di Kecamatan Pinggir Kabupaten Bengkalis, 2010-2015 [PDF]
, 2016 This research do to describe implementation preparation grand strategy program in Pinggir subdistrict as transit and petropolitan city. From the set of target program\u27s grand strategy has a span of five years, between years 2010-2015. But the expected
Anwar, K. (Khairul) +1 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Impact of good governance, economic growth and universal health coverage on COVID-19 infection and case fatality rates in Africa. [PDF]
Health Res Policy Syst, 2022 Gebremichael B +5 more
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Cape Verde: Marketing Good Governance Kap Verde: Die Vermarktung von Good Governance
Africa Spectrum, 2009 Faced with a lack of natural resources Cape Verde has made good governance one of its most marketable products. Running parallel to the institutionalisation of democratic politics there has been an overhaul and growing sophistication in public ...
Bruce Baker
doaj