Results 221 to 230 of about 1,187,046 (293)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Co-benefits of health: from evidence to governance, politics and advocacy. [PDF]

Eur J Public Health
Marchandise C, Falkenbach M, Siciliani L, Greer SL, Wismar M.   +4 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Responsiveness to City Service Requests, Life Satisfaction, and Horizontal Inequality: Does Good Local Governance Improve Subjective Well-Being for All? [PDF]

Int J Environ Res Public Health
Tharakan DPL, Ford TN.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The Kananaskis Wildfire Charter: a good start. [PDF]

Nat Commun
Yadav K, Croker A, Ford A, Hayes W, Kountouris Y, Millington J, Mistry J, Vicente MM, Perkins O, Schreckenberg K, Smith C, Stiefel M, Valette M.   +12 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Measuring the quality of species list governance. [PDF]

Bioscience
Garnett ST, Bánki O, Barik SK, Berryman AJ, Bouchard P, Buckeridge J, Christidis L, Cigliano MM, Conix S, Crawford-Weaver H, van Dijk PP, Evenhuis NL, Hilton-Taylor C, Hobern D, Johnston C, Klopper RR, Kroh A, Le Roux M, Pape T, Pyle RL, Raz L, Thomas P, Thomson S, Vandepitte L, Wambiji N, Zachos FE, Lien AM.   +26 more
europepmc   +1 more source