Results 221 to 230 of about 1,220,671 (347)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

WHO FCTC Article 19: Using the judicial system to fight tobacco

Tobacco Induced Diseases, 2020
Kelsey Romeo-Stuppy, Daniel Dorado, Davi Bressler, Deborah Sy, Amos Hausner   +4 more
doaj   +1 more source

Do reimbursement recommendation processes used by government drug plans in Canada adhere to good governance principles? [PDF]

Clinicoecon Outcomes Res, 2017
Rawson NS, Adams J.
europepmc   +1 more source

THE RELATIONSHIP OF THE ROLES OF BOTH CIVIL AND PRIVATE SOCIETY TOWARDS THE INDONESIAN GOVERNMENT THAT PRACTISES DESENTRALISED DEMOCRACY TO ACHIEVE GOOD GOVERNANCE

, 2018
Dadan Hidayatulloh, Utang Suwaryo, Affan Sulaeman, Nandang Alamsah Deliarnoor   +3 more
openalex   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Participatory health councils and good governance: healthy democracy in Brazil? [PDF]

Int J Equity Health, 2015
Kohler JC, Martinez MG.
europepmc   +1 more source

Good governance in Norway

, 2009
Harald Koht
openalex   +1 more source

Management of International Partnership in the Perspective of Good University Governance

, 2019
Anies Fortina Febriani, Drajat Tri Kartono, Didik G. Suharto   +2 more
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Public Health Genomics: the essential part for good governance in public health. [PDF]

Int J Public Health, 2016
Brand A, Evangelatos N, Satyamoorthy K.
europepmc   +1 more source