Results 41 to 50 of about 569,411 (259)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Tailor-made tests for goodness of fit to semiparametric hypotheses [PDF]
, 2006 We introduce a new framework for constructing tests of general semiparametric hypotheses which have nontrivial power on the $n^{-1/2}$ scale in every direction, and can be tailored to put substantial power on alternatives of importance.
Bickel, Peter J. +2 more
core +2 more sources
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
A common goodness-of-fit framework for neural population models using marked point process time-rescaling [PDF]
, 2018 A critical component of any statistical modeling procedure is the ability to assess the goodness-of-fit between a model and observed data. For spike train models of individual neurons, many goodness-of-fit measures rely on the time-rescaling theorem and ...
Arai, Kensuke +3 more
core +1 more source
Indonesian Journal of Pharmacy, 2021 The population-based approach has been widely applied to describe the pharmacokinetic profile of many drugs. The aim of this current research was to study the implementation of the population-based pharmacokinetics of levofloxacin in rabbits administered
Akhmad Kharis Nugroho +4 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Asymptotically distribution-free goodness-of-fit testing for tail copulas [PDF]
, 2014 Let $(X_1,Y_1),\ldots,(X_n,Y_n)$ be an i.i.d. sample from a bivariate distribution function that lies in the max-domain of attraction of an extreme value distribution.
Can, Sami Umut +3 more
core +3 more sources
On The Pros and Cons of Using Excel for Regression Analysis
Turkish Journal of Agriculture: Food Science and TechnologyExcel is a useful and powerful software for simple regression analysis without any programming skills and that is why, it is widely preferred by the undergraduate students from various areas such as chemistry, biology and agriculture as well as many ...
Sencer Buzrul
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Goodness-of-Fit Analysis of Radial Velocities Surveys
, 2000 Using eigenmode expansion of the Mark-3 and SFI surveys of cosmological radial velocities a goodness-of-fit analysis is applied on a mode-by-mode basis.
Hoffman, Yehuda, Zaroubi, Saleem
core +2 more sources