Results 61 to 70 of about 4,272,068 (257)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Goodness of Fit Test and Test of Independence by Entropy

Journal of Mathematical Extension, 2009
To test whether a set of data has a specific distribution or not, we can use the goodness of fit test. This test can be done by one of Pearson X 2 -statistic or the likelihood ratio statistic G 2 , which are asymptotically equal, and also by using
M. Sharifdoost, N. Nematollahi, E. Pasha
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

PENGEMBANGAN INVESTASI WILAYAH PERBATASAN, INDUSTRI MARITIM DAN KAWASAN PERDAGANGAN BEBAS DALAM MENINGKATKAN KESEJAHTERAAN MASYARAKAT PESISIR DI PROVINSI KEPULAUAN RIAU

Jurnal Pendidikan Ekonomi dan Bisnis (JPEB), 2017
The purpose of this research to create the boder region of investment development model, the maritime industry investment development model and Free Trade Zone development model effect on increase the welfare of coastal communities.The research location ...
Tumpal Manik , Henry Eryanto , Lia Suprihartini   +2 more
doaj   +1 more source

Expanded Fréchet Model: Mathematical Properties, Copula, Different Estimation Methods, Applications and Validation Testing

Mathematics, 2020
The extreme value theory is expanded by proposing and studying a new version of the Fréchet model. Some new bivariate type extensions using Farlie–Gumbel–Morgenstern copula, modified Farlie–Gumbel–Morgenstern copula, Clayton copula, and Renyi’s entropy ...
Mukhtar M. Salah, M. El-Morshedy, M. S. Eliwa, Haitham M. Yousof   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Multiscale image denoising using goodness-of-fit test based on EDF statistics.

PLoS ONE, 2019
Two novel image denoising algorithms are proposed which employ goodness of fit (GoF) test at multiple image scales. Proposed methods operate by employing the GoF tests locally on the wavelet coefficients of a noisy image obtained via discrete wavelet ...
Khuram Naveed, Bisma Shaukat, Shoaib Ehsan, Klaus D Mcdonald-Maier, Naveed Ur Rehman   +4 more
doaj   +1 more source

Goodness-of-Fit Test of Shapiro-Wilk Type with Nuisance Regression and Scale

Austrian Journal of Statistics, 2016
Shapiro and Wilk (1965) proposed a highly intuitive goodness-of-fit test of normality with nuisance location and scale parameters. The test has received a considerable attention in the literature; its asymptotic null distribution is covered by the ...
Pranab Kumar Sen, Jana Jurečková, Jan Picek   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source