Results 51 to 60 of about 761,301 (258)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
An Over and Underdispersed Biparametric Extension of the Waring Distribution
Mathematics, 2021 A new discrete distribution for count data called extended biparametric Waring (EBW) distribution is developed. Its name is related to the fact that, in a specific configuration of its parameters, it can be seen as a biparametric version of the ...
Valentina Cueva-López +2 more
doaj +1 more source
Goodness-of-fit criteria for survival data [PDF]
, 2004 The definition of an appropriate measure for goodness-of-fit in case of survival data comparable to R^2 in linear regression is difficult due to censored observations.
Müller, M.
core +2 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
An Exhaustive Power Comparison of Normality Tests
Mathematics, 2021 A goodness-of-fit test is a frequently used modern statistics tool. However, it is still unclear what the most reliable approach is to check assumptions about data set normality. A particular data set (especially with a small number of observations) only
Jurgita Arnastauskaitė +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Goodness of fit tests for Rayleigh distribution based on Phi-divergence
Revista Colombiana de Estadística, 2017 In this paper, we develop some goodness of fit tests for Rayleigh distribution based on Phi-divergence. Using Monte Carlo simulation, we compare the power of the proposed tests with some traditional goodness of fit tests including Kolmogorov-Smirnov ...
Mahdi Mahdizadeh , Ehsan Zamanzade
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Fatores que influenciam os parâmetros das curvas de lactação em cabras no Distrito Federal
Revista Brasileira de Zootecnia, 2003 O objetivo deste trabalho foi avaliar a influência de fatores ambientais sobre a forma de curvas de lactação (Quadrática, Gama, Linear Hiperbólica e Jenkins e Ferrel) de cabras das raças Saanen, Parda Alpina, Toggenburg e seus mestiços.
Concepta McManus +3 more
doaj