Results 21 to 30 of about 329,541 (261)

A machine-learning based objective measure for ALS disease severity

npj Digital Medicine, 2022
Amyotrophic Lateral Sclerosis (ALS) disease severity is usually measured using the subjective, questionnaire-based revised ALS Functional Rating Scale (ALSFRS-R).
Fernando G. Vieira, Subhashini Venugopalan, Alan S. Premasiri, Maeve McNally, Aren Jansen, Kevin McCloskey, Michael P. Brenner, Steven Perrin   +7 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Privacy-first health research with federated learning

npj Digital Medicine, 2021
Privacy protection is paramount in conducting health research. However, studies often rely on data stored in a centralized repository, where analysis is done with full access to the sensitive underlying content.
Adam Sadilek, Luyang Liu, Dung Nguyen, Methun Kamruzzaman, Stylianos Serghiou, Benjamin Rader, Alex Ingerman, Stefan Mellem, Peter Kairouz, Elaine O. Nsoesie, Jamie MacFarlane, Anil Vullikanti, Madhav Marathe, Paul Eastham, John S. Brownstein, Blaise Aguera y. Arcas, Michael D. Howell, John Hernandez   +17 more
doaj   +1 more source

Cross-modal distillation for flood extent mapping

Environmental Data Science, 2023
The increasing intensity and frequency of floods is one of the many consequences of our changing climate. In this work, we explore ML techniques that improve the flood detection module of an operational early flood warning system.
Shubhika Garg, Ben Feinstein, Shahar Timnat, Vishal Batchu, Gideon Dror, Adi Gerzi Rosenthal, Varun Gulshan   +6 more
doaj   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Evaluation of a Novel Electric Health Record Sidecar Application to Display Rheumatoid Arthritis Clinical Outcomes During Clinic Visits: Results of a Stepped‐Wedge Cluster Randomized Pragmatic Trial

Arthritis Care &Research, EarlyView.
Objective We developed a novel electronic health record sidecar application to visualize key rheumatoid arthritis (RA) outcomes, including disease activity, physical function, and pain, via a patient‐facing graphical interface designed for use during outpatient visits (“RA PRO dashboard”).
Gabriela Schmajuk, Jing Li, Cathy Nasrallah, Cherish Wilson, Alicia Hamblin, Christine Hariz, Cammie Young, Stephen Shiboski, Emma Kersey, Mary Nakamura, Judith F. Ashouri, Mehrdad Matloubian, Andrew J. Gross, Jennifer Barton, Beth Berrean, Jonathan Prugh, Jinoos Yazdany   +16 more
wiley   +1 more source

Decoding quantum errors with subspace expansions

Nature Communications, 2020
Fault-tolerant quantum computation is still far, but there could be ways in which quantum error correction could improve currently available devices. Here, the authors show how to exploit existing quantum codes through only post-processing and random ...
Jarrod R. McClean, Zhang Jiang, Nicholas C. Rubin, Ryan Babbush, Hartmut Neven   +4 more
doaj   +1 more source

What Do Large Language Models Know About Materials?

Advanced Engineering Materials, EarlyView.
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer, Thomas Wallmersperger, Gianaurelio Cuniberti   +2 more
wiley   +1 more source

A population-specific reference panel for improved genotype imputation in African Americans

Communications Biology, 2021
O’Connell et al. construct a new genome-wide imputation reference panel comprising 2,269 individuals of Sub-Saharan African ancestries. They adapt DeepVariant to create best practices for reference panel development and generate a high quality, publicly ...
Jared O’Connell, Taedong Yun, Meghan Moreno, Helen Li, Nadia Litterman, Alexey Kolesnikov, Elizabeth Noblin, Pi-Chuan Chang, Anjali Shastri, Elizabeth H. Dorfman, Suyash Shringarpure, 23andMe Research Team, Adam Auton, Andrew Carroll, Cory Y. McLean   +14 more
doaj   +1 more source