Results 41 to 50 of about 1,019 (146)

Alcian blue‐positive stromal phenotype in basal cell carcinoma is associated with progression on first‐line hedgehog inhibitors

The Journal of Pathology: Clinical Research, Volume 12, Issue 1, January 2026.
Abstract Basal cell carcinoma (BCC) is the most frequent malignancy in fair‐skinned populations. Although curable in most cases, approximately 4% of patients develop locally advanced or metastatic disease (advBCC) requiring systemic therapy. Hedgehog pathway inhibitors (HHIs; vismodegib/sonidegib) constitute standard first‐line treatment, yet ...
Viola K DeTemple, Rudolf Stadler, Sabine Bredemeier, Sungyoung Chung, Katrin Schaper‐Gerhardt, Mareike Alter, Yenny Angela, Henner Stege, Ulrike Leiter, Jan Ohletz, Elisabeth Livingstone, Imke von Wasielewski, Jessica C Hassel, Julia Huynh, Christoffer Gebhardt, Claudia Pföhler, Ralf Gutzmer, Christina H Scheel   +17 more
wiley   +1 more source

Síndrome de Gorlin-Goltz: revisão das características neurorradiológicas e maxilofaciais ilustradas com dois casos.

Acta Médica Portuguesa, 2010
Gorlin-Goltz syndrome or nevoid basal cell carcinoma syndrome is a rare hereditary autosomal-dominant disorder characterized by multiple basal cell carcinomas in young patients, odontogenic keratocysts, palmar or plantar pits, calcification of the falx ...
Marta Maia Safronova, Mavilde Arantes, Iva Lima, Sara Domingues, Marta Almeida, Pedro Moniz   +5 more
doaj   +1 more source

Worth the Effort: Lessons for Discovery and Care From an Unusual Case of Gorlin Syndrome

American Journal of Medical Genetics Part A, Volume 197, Issue 9, September 2025.
ABSTRACT Gorlin‐Goltz Syndrome (GGS) is a rare autosomal dominant genetic disorder encompassing a diverse range of clinical manifestations, including congenital anomalies and predisposition to cancer. Pathogenic variants in PTCH1 and SUFU account for up to 79% and 6% of cases, respectively. Currently, an estimated 15%–27% of individuals with a clinical
V. Taliercio, J. Zhao, S. E. Boyden, R. Mao, P. Bayrak‐Toydemir, A. Pflaum, J. Palumbos, A. Andrews, E. E. Baldwin, C. Welt, Mackenzie Fait, Undiagnosed Diseases Network, L. D. Botto, D. Viskochil   +13 more
wiley   +1 more source

Nevoid basal cell carcinoma syndrome

Indian Journal of Dental Research, 2006
Binkley and Johnson first reported this syndrome in 1951. But it was in 1960, Gorlin-Goltz established the association of basal cell epithelioma, jaw cyst and bifid ribs, a combination which is now frequently known as Gorlin-Goltz syndrome as well as ...
Kannan Karthiga, Sundharam Sivapatha, Manikandan R   +2 more
doaj  

Ventral body wall closure: Mechanistic insights from mouse models and translation to human pathology

Developmental Dynamics, Volume 254, Issue 2, Page 102-141, February 2025.
Abstract The ventral body wall (VBW) that encloses the thoracic and abdominal cavities arises by extensive cell movements and morphogenetic changes during embryonic development. These morphogenetic processes include embryonic folding generating the primary body wall; the initial ventral cover of the embryo, followed by directed mesodermal cell ...
Caroline Formstone, Bashar Aldeiri, Mark Davenport, Philippa Francis‐West   +3 more
wiley   +1 more source

A rare case of Gorlin–Goltz syndrome

The Egyptian Journal of Radiology and Nuclear Medicine
Background The Gorlin–Goltz syndrome (the Nevoid basal cell carcinoma syndrome (NBCCS)) is reviewed as a rare autosomal dominant syndrome caused by gene mutations located on chromosome arm 9 q.
Sara R. Hassan, Ayda A. Youssef, Esraa S. ElMallah   +2 more
doaj   +1 more source

Focal dermal hypoplasia: A novel finding in disguise

Journal of Oral Biology and Craniofacial Research, 2018
Focal Dermal Hypoplasia (FDH) or Goltz-Gorlin syndrome is an unusual X-linked dominant syndrome characterised by anomalies of both ectodermal and mesodermal structures.We present a case report on the management of a 58 year old Caucasian male with Focal ...
S. Nathwani, K. Martin, R. Bunyan
doaj   +1 more source

The role of electrochemotherapy in the treatment of locally advanced or recurrent eyelid‐periocular basal cell carcinoma: long‐term results

International Journal of Dermatology, Volume 64, Issue 1, Page 111-118, January 2025.
Abstract Background While electrochemotherapy (ECT) is increasingly utilized as a highly effective method in the treatment of tumors in the head and neck region, there is significantly less data available for eyelid‐periocular skin tumors. Our group reported the first extensive case series of eyelid‐periocular basal cell carcinoma (BCC) patients with ...
Attila Vass, Nóra Polgár, Szilvia Alexa Sándor, Dóra Ágoston, Petra Rózsa, Ildikó Csányi, Henriette Ócsai, Eszter Baltás, Judit Oláh, Erika Gabriella Kis, Edit Tóth‐Molnár   +10 more
wiley   +1 more source

Delayed Pulmonary Metastasis of Basal Cell Carcinoma 10 Years After Primary Excision: A Case Report and Literature Review

Case Reports in Medicine, Volume 2025, Issue 1, 2025.
Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy, characterized by slow progression and a low propensity for metastasis. Metastatic basal cell carcinoma (mBCC) occurs in fewer than 0.1% of the cases, most frequently involving the lungs, lymph nodes, or bones.
Hazhir Moradi, Negar Karavan, Forough Kalantari, Elham Kalantari, Viswanatha Borlingegowda   +4 more
wiley   +1 more source

Plaque‐type trichoblastoma and its siblings: A (follicular tumour) family history

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Ines Bertlich, Ferdinand Toberer, Tilman Schulz, Dmitry V. Kazakov, Wolfgang Hartschuh   +4 more
wiley   +1 more source