Results 51 to 60 of about 1,227,204 (147)

Alcian blue‐positive stromal phenotype in basal cell carcinoma is associated with progression on first‐line hedgehog inhibitors

The Journal of Pathology: Clinical Research, Volume 12, Issue 1, January 2026.
Abstract Basal cell carcinoma (BCC) is the most frequent malignancy in fair‐skinned populations. Although curable in most cases, approximately 4% of patients develop locally advanced or metastatic disease (advBCC) requiring systemic therapy. Hedgehog pathway inhibitors (HHIs; vismodegib/sonidegib) constitute standard first‐line treatment, yet ...
Viola K DeTemple, Rudolf Stadler, Sabine Bredemeier, Sungyoung Chung, Katrin Schaper‐Gerhardt, Mareike Alter, Yenny Angela, Henner Stege, Ulrike Leiter, Jan Ohletz, Elisabeth Livingstone, Imke von Wasielewski, Jessica C Hassel, Julia Huynh, Christoffer Gebhardt, Claudia Pföhler, Ralf Gutzmer, Christina H Scheel   +17 more
wiley   +1 more source

A rare case of Gorlin–Goltz syndrome

The Egyptian Journal of Radiology and Nuclear Medicine
Background The Gorlin–Goltz syndrome (the Nevoid basal cell carcinoma syndrome (NBCCS)) is reviewed as a rare autosomal dominant syndrome caused by gene mutations located on chromosome arm 9 q.
Sara R. Hassan, Ayda A. Youssef, Esraa S. ElMallah   +2 more
doaj   +1 more source

Síndrome de Gorlin-Goltz: revisão das características neurorradiológicas e maxilofaciais ilustradas com dois casos.

Acta Médica Portuguesa, 2010
Gorlin-Goltz syndrome or nevoid basal cell carcinoma syndrome is a rare hereditary autosomal-dominant disorder characterized by multiple basal cell carcinomas in young patients, odontogenic keratocysts, palmar or plantar pits, calcification of the falx ...
Marta Maia Safronova, Mavilde Arantes, Iva Lima, Sara Domingues, Marta Almeida, Pedro Moniz   +5 more
doaj   +1 more source

Male Goltz Syndrome due to Postzygotic PORCN Mosaicism: A Case Report

Case Reports in Dermatological Medicine, Volume 2026, Issue 1, 2026.
Goltz syndrome, also known as focal dermal hypoplasia (FDH), is a rare X‐linked dominant genetic disorder caused by loss‐of‐function mutations in the PORCN gene, which is crucial for Wnt protein secretion and signaling during embryonic development.
Vu Anh Dao Tran, Mohammed Eldoadoa, Tong Ba Tran, Nhi Thi Uyen Pham, Lam D. Chau, Abdelrahman M. Makram, Nguyen Tien Huy, Thuy Thi Phan Nguyen, Randa Elsheikh, Semonti Nandi   +9 more
wiley   +1 more source

Multiple Odontogenic Keratocysts as the Initial Manifestation of Gorlin Syndrome in a Child: A Case Report With Conservative Management and Diagnostic Considerations

Case Reports in Dentistry, Volume 2026, Issue 1, 2026.
Multiple odontogenic keratocysts are one of the major diagnostic criteria of Gorlin syndrome and may represent an early manifestation of the disorder in pediatric patients. This report describes the diagnostic process and management of an 11‐year‐old boy who presented with multiple mandibular cystic lesions associated with displacement of developing ...
V. Anguera-Ortega, P. Cahuana-Bartra, L. Brunet-Llobet, Y. González-Chópite, E. I. Mashala, J. Miranda-Rius, Priya Gusain   +6 more
wiley   +1 more source

Focal dermal hypoplasia: A novel finding in disguise

Journal of Oral Biology and Craniofacial Research, 2018
Focal Dermal Hypoplasia (FDH) or Goltz-Gorlin syndrome is an unusual X-linked dominant syndrome characterised by anomalies of both ectodermal and mesodermal structures.We present a case report on the management of a 58 year old Caucasian male with Focal ...
S. Nathwani, K. Martin, R. Bunyan
doaj   +1 more source

Plaque‐type trichoblastoma and its siblings: A (follicular tumour) family history

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Ines Bertlich, Ferdinand Toberer, Tilman Schulz, Dmitry V. Kazakov, Wolfgang Hartschuh   +4 more
wiley   +1 more source

Syndromic Multiple Odontogenic Keratocysts Associated With Impacted Teeth: A Rare Case Report

Case Reports in Dentistry, Volume 2026, Issue 1, 2026.
Introduction Odontogenic keratocysts are developmental odontogenic cysts that may occur as solitary lesions or as multiple jaw lesions. Multiple odontogenic keratocysts in young patients should raise suspicion of an underlying syndrome, particularly Gorlin–Goltz syndrome.
Faizal Manrapi, Mohammad Gazali, Nurwahida, Nisrina Ekayani Nasrun, Hannah Wesley   +4 more
wiley   +1 more source

Vulvar Apocrine Hidrocystoma: A Rare Case Report

Case Reports in Obstetrics and Gynecology, Volume 2026, Issue 1, 2026.
Apocrine hidrocystoma is a rare and benign tumor that usually occurs on the head, neck, and face. Involvement of the vulva is extremely rare, with only a few documented case reports in the literature. The prognosis of the tumor is favorable with surgical excision, with no reported recurrences.
Nastaran Mahmoudnejad, Peyman Mohammadi Torbati, Niloofar Irandoost, Karuna Sharma   +3 more
wiley   +1 more source

Nevoid basal cell carcinoma syndrome (Gorlin-Goltz syndrome). Case report [PDF]

, 2013
Gorlin-Goltz syndrome or nevoid basal cell carcinoma syndrome (NBCCS) comprises multiple basal cell carcinomas, keratocysts of the jaw, palmar/plantar pits, spine and rib anomalies, calcifications of the falx cerebri etc.
Belli, E., Fini, Giuseppina, Virciglio, Pasquale, Mici, Elidon, D'Itri, L., Pasta, Vittorio, Malavenda, M.S., Krizzuk, D., Maturo, A., Merola, R., Moricca, Luca Maria, Leonardi, A.   +11 more
core   +2 more sources