Results 91 to 100 of about 929 (110)

Pacific community's perceptions on how to improve uptake of urate-lowering therapy for Pacific gout patients. [PDF]

Int J Equity Health
Ofanoa S, Ofanoa M, Tu'akoi S, Lutui H, Heather M, Goodyear-Smith F.   +5 more
europepmc   +1 more source

The Influence of Patient Factors on the Population Pharmacokinetics of Colchicine: Implications for Safe and Effective Dosing. [PDF]

Clin Pharmacokinet
Wright DFB, Hishe HZ, Dalbeth N, Horne A, Drake J, Haslett J, Stamp LK.   +6 more
europepmc   +1 more source

Comparison of pharmacokinetic and pharmacodynamic properties of allopurinol and benzbromarone in a quail model of hyperuricemia. [PDF]

J Vet Sci
Zheng S, Bu Y, Li S, Chen N.
europepmc   +1 more source

An Analysis of Cost Variation Among Drugs Available in the Indian Market for the Treatment of Chronic Bone-Related Ailments. [PDF]

Cureus
Jayachandran M, Geevarughese NM, Palatty PL, Baliga-Rao MP, Sacheendran D, Baliga MS.   +5 more
europepmc   +1 more source

NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice

Journal of Molecular Endocrinology, 2021
Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal-induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with upregulated caspase 1 protease and IL-1β in macrophages.
Ying, Xue, Ran, Li, Ping, Fang, Zheng-Qin, Ye, Yong, Zhao, Yun, Zhou, Ke-Qin, Zhang, Ling, Li   +7 more
openaire   +2 more sources

Opposite effects of cations in enhancing and suppressing nucleation in the pathological crystallization of gout

CrystEngComm, 2021
“Opposite effects” were shown by cations, enhancing nucleation followed by suppressing nucleation at physiological pH and ionic strength.
Anqi Da, Aijun Ren, Rong Cheng, Xingde Zhang, Yonglan Pan, Chunyan Ou, Tingming Fu, Yonghai Liu   +7 more
openaire   +1 more source

Baeckein E suppressed NLRP3 inflammasome activation through inhibiting both the priming and assembly procedure: Implications for gout therapy

Phytomedicine, 2021
Baeckein E (BF-2) was isolated from the aerial parts of Baeckea frutescens L., which has a long history of use in traditional medicine in Southeast Asia to treat inflammatory disease.BF-2 was identified to have inhibitory activity on nucleotide oligomerization domain (NOD)-like receptor protein-3 inflammasome (NLRP3) activation.
Xiaobing Lin, Hao Wang, Xiaofei An, Junhan Zhang, Jin Kuang, Jiqin Hou, Ming Yan   +6 more
openaire   +2 more sources

Self-suppression from metabolin with a precursor in pathology crystallization of gout

CrystEngComm, 2019
Hyperuricemia is typically defined as occurring above the saturation point of monosodium urate monohydrate (MSUM), which occurs at serum urate levels >6.8 mg dL−1.
Yonghai Liu, Jie Jing, Chunyan Ou, Xingde Zhang, Shengyu Jiang, Rong Chen, Tingming Fu   +6 more
openaire   +1 more source

Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways

Acta Pharmacologica Sinica, 2021
Monosodium urate (MSU) crystals, the etiological agent of gout, are formed in joints and periarticular tissues due to long-lasting hyperuricemia. Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1β (IL-1β) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also ...
Chun-Su, Zhong, Bo, Zeng, Jia-Hao, Qiu, Li-Hui, Xu, Mei-Yan, Zhong, Yuan-Ting, Huang, Rong, Xu, Si-Ying, Liu, Qing-Bing, Zha, Bo, Hu, Dong-Yun, Ou-Yang, Xian-Hui, He   +11 more
openaire   +2 more sources

Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation

Journal of Agricultural and Food Chemistry, 2018
Gout arthritis is a painful inflammatory disease induced by monosodium urate (MSU) crystals. We evaluate the therapeutic potential of the flavonoid hesperidin methylchalcone (HMC) in a mouse model of gout arthritis induced by intra-articular injection of MSU (100 μg/10 μL).
Kenji W. Ruiz-Miyazawa, Felipe A. Pinho-Ribeiro, Sergio M. Borghi, Larissa Staurengo-Ferrari, Victor Fattori, Flavio A. Amaral, Mauro M. Teixeira, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri   +11 more
openaire   +2 more sources