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Phytomedicine, 2021
Baeckein E (BF-2) was isolated from the aerial parts of Baeckea frutescens L., which has a long history of use in traditional medicine in Southeast Asia to treat inflammatory disease.BF-2 was identified to have inhibitory activity on nucleotide oligomerization domain (NOD)-like receptor protein-3 inflammasome (NLRP3) activation.
Xiaobing Lin +6 more
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Baeckein E (BF-2) was isolated from the aerial parts of Baeckea frutescens L., which has a long history of use in traditional medicine in Southeast Asia to treat inflammatory disease.BF-2 was identified to have inhibitory activity on nucleotide oligomerization domain (NOD)-like receptor protein-3 inflammasome (NLRP3) activation.
Xiaobing Lin +6 more
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Self-suppression from metabolin with a precursor in pathology crystallization of gout
CrystEngComm, 2019Hyperuricemia is typically defined as occurring above the saturation point of monosodium urate monohydrate (MSUM), which occurs at serum urate levels >6.8 mg dL−1.
Yonghai Liu +6 more
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Acta Pharmacologica Sinica, 2021
Monosodium urate (MSU) crystals, the etiological agent of gout, are formed in joints and periarticular tissues due to long-lasting hyperuricemia. Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1β (IL-1β) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also ...
Chun-Su, Zhong +11 more
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Monosodium urate (MSU) crystals, the etiological agent of gout, are formed in joints and periarticular tissues due to long-lasting hyperuricemia. Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1β (IL-1β) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also ...
Chun-Su, Zhong +11 more
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Journal of Agricultural and Food Chemistry, 2018
Gout arthritis is a painful inflammatory disease induced by monosodium urate (MSU) crystals. We evaluate the therapeutic potential of the flavonoid hesperidin methylchalcone (HMC) in a mouse model of gout arthritis induced by intra-articular injection of MSU (100 μg/10 μL).
Kenji W. Ruiz-Miyazawa +11 more
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Gout arthritis is a painful inflammatory disease induced by monosodium urate (MSU) crystals. We evaluate the therapeutic potential of the flavonoid hesperidin methylchalcone (HMC) in a mouse model of gout arthritis induced by intra-articular injection of MSU (100 μg/10 μL).
Kenji W. Ruiz-Miyazawa +11 more
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The Journal of Immunology, 2017
Abstract The NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, which is composed of NLRP3, the adaptor protein ASC, and caspase-1, is closely linked to the pathogenesis of metabolic diseases. We investigated whether caffeic acid phenethyl ester (CAPE), an anti-inflammatory phytochemical, could modulate the ...
Hye Eun Lee, Gabsik Yang, Joo Young Lee
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Abstract The NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, which is composed of NLRP3, the adaptor protein ASC, and caspase-1, is closely linked to the pathogenesis of metabolic diseases. We investigated whether caffeic acid phenethyl ester (CAPE), an anti-inflammatory phytochemical, could modulate the ...
Hye Eun Lee, Gabsik Yang, Joo Young Lee
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Suppression of the manifestations of gout with continuous cortisone therapy
The American Journal of Medicine, 1954Abstract Suppression of acute arthritic attacks and mobilization of solid, presumably tophaceous, deposits in a patient with gout by the prolonged daily administration of cortisone is described. Increasing effectiveness of the drug with the passage of time was observed.
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Phytomedicine
Gout is an arthritic disorder caused by the deposition of sodium urate crystals in the joints. Phaseoloidin (PHA), a β-glucoside of homogentisic acid isolated from the seeds of the legume "Entada phaseoloides (L.) Merr.", has previously showed anti-inflammatory properties, but its effects on gout and underlying mechanisms remain unexplored.This study ...
Yin-Jing Jiang +6 more
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Gout is an arthritic disorder caused by the deposition of sodium urate crystals in the joints. Phaseoloidin (PHA), a β-glucoside of homogentisic acid isolated from the seeds of the legume "Entada phaseoloides (L.) Merr.", has previously showed anti-inflammatory properties, but its effects on gout and underlying mechanisms remain unexplored.This study ...
Yin-Jing Jiang +6 more
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Food & Function
Limonin restored UA homeostasis by simultaneously regulating UA excretion and production. It alleviated hepatorenal damage and inflammation by binding to AMPK, thereby suppressing downstream inflammatory activation.
Minjie Zeng +9 more
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Limonin restored UA homeostasis by simultaneously regulating UA excretion and production. It alleviated hepatorenal damage and inflammation by binding to AMPK, thereby suppressing downstream inflammatory activation.
Minjie Zeng +9 more
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Archives of Biochemistry and Biophysics
The aim of the current study was to investigate the potential therapeutic effect of kaurenoic acid (KA) against Monosodium Urate Crystals (MSU)-induced acute gout by downregulation of NF-κB signaling pathway, mitigating inflammation and oxidative stress.
Maryam, Jamil +8 more
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The aim of the current study was to investigate the potential therapeutic effect of kaurenoic acid (KA) against Monosodium Urate Crystals (MSU)-induced acute gout by downregulation of NF-κB signaling pathway, mitigating inflammation and oxidative stress.
Maryam, Jamil +8 more
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How effective is allopurinol at suppressing recurrent gout attacks?
Evidence-Based Practice, 2016Jennifer Cook +3 more
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