Results 71 to 80 of about 248,604 (262)

Economic Contribution of the Department of Agriculture 4K Program of Local Government Unit in Southern Philippines: Basis for Program Enhancement [PDF]

SHS Web of Conferences
This study determines the economic contribution of the Department of Agriculture’s 4K (Kabuhayan at Kaunlaran ng Kababayang Katutubo) program to beneficiaries of Local government unit in Southern Philippines, an Indigenous community. It also assesses the
Bandahan Mary Rose P., Dumaog Czharralhyn Davone L., Carlos Angelene C., Lubos Lalevie C.   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Synergy of energy alternatives, FinTech, and natural resources on SDG13: results from panel QCA and econometric models

Discover Sustainability
This study investigates the synergistic effects of energy alternatives, financial technology (FinTech), natural resources, and climate action within the BRICS nations, with a focus on achieving Sustainable Development Goal 13 (SDG13), which centers on ...
Md. Mominur Rahman, Tasfia Tasneem Ahmed, Nafisa Binte Farid Prova, Sultan Ahmed   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Optimizing the health workforce for Universal Health Coverage: a framework for analysis and action

Human Resources for Health
Background The health workforce or human resources for health (HRH) is the bedrock of an efficient healthcare system, and the consequences of HRH shortage are evident in poor health service delivery.
Gafar B. Alawode, Abdul-Rahman A. Ajibola, Morohunranti S. Sanusi, Ayomide B. Adewoyin, Kafayat A. Alawode   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Transformation Across Land-Sea Governance: Future Research Opportunities

Ocean and Society
Transformation is heralded as a solution to the diverse and interconnected crises threatening natural environments and the livelihoods of those who depend on them.
Tegan Evans, Gianluca Ferraro, Pierre Failler   +2 more
doaj   +1 more source

Strengthening and redesigning flood risk governance in Europe: an overview of seven key issues and how they are being dealt with in six European countries

E3S Web of Conferences, 2016
European countries, especially urban areas, face increasing flood risks due to urbanization, increase of exposure and damage potential, and the effects of climate change.
Hegger Dries, Driessen Peter, Bakker Marloes, Dieperink Carel   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source