Results 51 to 60 of about 157,408 (308)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Exploring the potential of blockchain technology for citizen engagement in smart governance [version 3; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
This review article explores the potential of blockchain technology (BCT) as a key enabler for fostering transparency, trust, and citizen engagement in smart governance within smart cities.
Rebecca Marconi, Edna Pasher, Niccolò Testi   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A theoretical framework for analysing the contribution of education to sustainable peacebuilding: 4Rs in conflict-affected contexts [PDF]

, 2015
This paper presents the theoretical and analytic framework for a Research Consortium on Education and Peacebuilding supported by UNICEF’s Peacebuilding, Education and Advocacy (PBEA) programme which began in July 2014 led by the Universities of Amsterdam,
Lopes Cardozo, Mieke, Novelli, Mario, Smith, Alan   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Modularity and Relational Mechanisms of Governance: An Analysis of Modular Consortium and Industrial Condominium

Journal of Operations and Supply Chain Management, 2013
This article analyzed the main mechanisms in inter-firm governance present in a modularconsortium as well as in an automotive industry industrial condominium, operating in Brazil.. The datacollection was carried out through interviews (in loco) in both automakers and suppliers. Modularconsortium and industrial condominium not only involve collaborative
Neto, Mario Sacomano, Pires, Sílvio Roberto Ignácio, da Silva, Eliciane Maria   +2 more
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Navigating the complexity of a collaborative, system-wide public health programme: learning from a longitudinal qualitative evaluation of the ActEarly City Collaboratory

Health Research Policy and Systems
Background Addressing the upstream social determinants of health (e.g. built environment, education) can reduce the burden of non-communicable diseases. To do so effectively often requires system-wide collaboration. However, collaborating across multiple
Laura Nixon, Laura Sheard, Jessica Sheringham, Amy Creaser, Halima Iqbal, Patience Gansallo, Liina Mansukoski, Maria Bryant, Bridget Lockyer   +8 more
doaj   +1 more source

Implementing the Dream: Lessons from the Houston Community College [PDF]

, 2008
With a commitment to affordable, open access education, community colleges provide a key access point to higher education, especially for low-income students and students of color. Using a qualitative approach, this report analyzes the experiences of six
at Virginia Commonwealth University, The Grace E. Harris Leadership Institute, Gooden, Susan, Martin, Kasey J   +2 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source