Results 61 to 70 of about 746,677 (306)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Boards in the Balance: Governing Higher Education Amid Anti-DEI Policy

AERA Open
This study explored how public higher education governing boards interpret and respond to anti–diversity, equity, and inclusion (anti-DEI) legislation.
Ishara Casellas Connors, Nathan Peterson, Mikayla Slaydon, Alfredo Valenzuela   +3 more
doaj   +1 more source

Clinical leadership in service redesign using Clinical Commissioning Groups: a mixed-methods study [PDF]

, 2018
Background: A core component of the Health and Social Care Act 2012 (Great Britain. Health and Social Care Act 2012. London: HMSO; 2012) was the idea of devolving to general practitioners (GPs) a health service leadership role for service redesign.
Abbott, Aveling, Battilana, Bourgeault, British Medical Association, Care Quality Commission, Checkland, Cloutier, Coombs, Currie, Currie, Cyert, Darzi, Denis, Denis, Denis, Dent, Department of Health, Dickinson, DiMaggio, Edwards, Eisenhardt, Eisenhardt, Field, Fitzgerald, Francis, Glaser, Great Britain, Great Britain, Greenhalgh, Greenwood, Greenwood, Gronn, Guthrie, Guthrie, Ham, Hartley, Heifetz, Heifetz, Heracleous, Ibarra, Imison, Ipsos, Kellog, Klein, Lawrence, Lawrence, Lawrence, Le Grand, Lincoln, Mays, McNulty, Miles, Miller, Moon, National Improvement and Leadership Development Board, Newman, NHS Confederation, NHS England, NHS England, NHS England, NHS England, NHS England, NHS England, NHS England and NHS Improvement, Packwood, PricewaterhouseCoopers, Radnor, Reay, Robertson, Robertson, Saks, Sanders, Seo, Sharpe, Sheaff, Smith, Spillane, Spurgeon, Storey, Storey, Storey, Storey, Storey, The Academy of Medical Sciences, The Health Foundation, The King’s Fund, Thornton, Touati, West, Williams   +90 more
core   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

El Asesor Cultural de la Junta de Gobierno. Alba y ocaso del primer hombre de la cultura bajo la dictadura cívico-militar chilena

Nuevo mundo - Mundos Nuevos, 2019
This article studies the Culture Adviser of the Government Board, examining the man behind this position, his coordination with the governmental cultural apparatus, his trajectory in the vagaries of official politics and the ideological conflicts that ...
Matías Alvarado Leyton
doaj   +1 more source

Possible impact of corporate governance profile on a Russian bank valuation [PDF]

, 2008
This paper aims at explaining the differences in valuation of banking firms in Russia through the impact of selected elements of corporate governance. We rely upon value-based management theory to test the hypothesis that expenses on corporate governance
Bokov, V., Vernikov, A.
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Making sense of co-operative governance: competing models and tensions

, 2002
This paper focuses on how cooperatives and mutual associations are governed. At the heart of these arrangements is an organisation's governing body or board.
Cornforth, Chris
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Corrigendum: Citizen science interactions with official geospatial information; Case studies from Mexico

Frontiers in Environmental Science, 2023
Céline Jacquin, Paloma Merodio Gómez, Vivian Arriaga, Andrea Santiago   +3 more
doaj   +1 more source