Results 31 to 40 of about 13,948 (270)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Government launches green paper on mental health [PDF]

BMJ, 1999
Health secretary Alan Milburn this week published proposals for a reform of the Mental Health Act 1983, as part of his plans to modernise the NHS in England and Wales. Patients discharged from psychiatric hospitals will be given orders specifying where they will live and what treatment they will have. If they break the terms of the order, they will be
openaire   +2 more sources

Governance and Susceptibility in Conflict Resolution: Possibilities Beyond Control [PDF]

, 2007
Governmentality analysis offers a nuanced critique of informal Western conflict resolution by arguing that recently emerged alternatives to adversarial court processes both govern subjects and help to constitute rather than challenge formal regulation ...
Abel, Richard L., Abel, Richard L., Atkinson, Paul, Attwood, Bain, Avruch, Kevin, Barry, Andrew, Bochner, Arthur P., Brown, David, Butler, Judith, Cloke, Kenneth, Dean, Mitchell, Dean, Mitchell, Deleuze, Gilles, Fitzpatrick, Peter, Flaherty, Michael G., Foucault, Michel, Foucault, Michel, Foucault, Michel, Foucault, Michel, Foucault, Michel, Foucault, Michel, Hindess, B., Langton, Marcia, Levinas, Emmanuel, Levinas, Emmanuel, Levinas, Emmanuel, Lingis, Alphonso, Lingis, Alphonso, Lingis, Alphonso, Matthews, Roger, Morgan Brigg, Muecke, Stephen, Muecke, Stephen, Neumann, Mark, O’Malley, Pat, Reed-Danahay, Deborah E., Rose, Deborah Bird, Rose, Deborah Bird, Rose, Nikolas, Sparkes, Andrew C., Stanner, W. E. H., Thomas, Nicholas, Voyce, Malcolm, Williams, Nancy, Williams, Nancy   +44 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

GOVERNANCE IN MENTAL HEALTH NURSING

, 2020
Introduction: Governance is a term that is applied to gather all activities that promote, review, measure and monitor the quality of patient care into an integrated and coherent whole. The aim is to adhere to the concept of governance in psychiatric nursing. This research method uses a literature review searching electronic data base.
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Autonomy of the family in the modern world

Horyzonty Wychowania, 2017
RESEARCH OBJECTIVE: The purpose of this article is to understand autonomy of the family in the ‘modern’ world by locating the family in the historical changes that led to its present form.
Nidhi Gulati
doaj