Results 61 to 70 of about 4,263,955 (339)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Phenomenon of the “dawn attacks operation” as a money politics practices in Indonesian election

open access: yesOtoritas: Jurnal Ilmu Pemerintahan
The practice of handing out money before voting or dawn raids is still the choice of some legislative candidates to gain votes from citizens. Dawn attacks as a practice of money politics are an act of malpractice that can damage the democratic essence of
Yusa Djuyandi, Diana Mahmuda
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Optimization of Mechanical Characteristics of Low-priced Breadfruit Peel Waste by Impregnating Low Density Polyethylene for Production Printer Components

open access: yesJournal of Applied Sciences and Environmental Management
The objective of this paper is the optimization of mechanical characteristics of low-priced breadfruit peel (BRP) waste by impregnating low density polyethylene (LPDE) for production printer components using appropriate standard procedure.
R. M. Government, S. Ayuba
doaj  

1 Mayıs 1977 Olaylarının Basın Üzerinden Değerlendirilmesi

open access: yesAtatürk Dergisi
1 Mayıs 1889’da işçi bayramı olarak kabul edilmiş ve dünya genelinde kutlanmaya başlanmıştır. Devlet sınırları içerisinde ilk işçi bayramı 1909’da Üsküp’te kutlanmıştır. 1911’de Selanik’te, 1912’de de İstanbul'da kutlanmıştır.
Tuba Özhazinedar
doaj   +1 more source

What is a "Regime of Truth"?

open access: yesGenealogy+Critique, 2015
In this paper, I offer an overview of the ways in which Foucault defines and uses the concept of 'regime of truth' in his works between 1975 and 1980, focusing especially on his lectures at the Collège de France On the Government of the Living.
Daniele Lorenzini
doaj   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

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