Results 111 to 120 of about 6,625,613 (395)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
IEEE Access, 2018 The illegal use of electronic seals has the potential to harm both the contracting parties and the country's economy. This paper studies the phylogenetic relationship between government regulatory bodies and enterprise behaviors through the payoff matrix
Hejun Liang +4 more
doaj +1 more source
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Earth System Governance, 2019 Cities are key in climate mitigation and adaptation, and they have developed into sites of innovative urban climate governance that can spur on climate action.
Jeroen van der Heijden
doaj
Essays on government regulation and government governance structure
, 2017 This thesis consists of two independent studies. The first study works on the effect of government regulation on financial markets. The second study analyses the multitask nature of government regulation in a regionally decentralized authoritarian regime.
openaire +2 more sources
A Political Economy Model of Regulation Explained Through Fuzzy Logics [PDF]
The basic problem of environmental regulation involves the government trying to induce a polluter to take socially desirable actions, which ostensibly are not in the best interest of the polluter.
Elizabeth Real Oliveira +1 more
core
The Size and Role of Government Economic Issues [PDF]
, 2008 [Excerpt] The size and role of the government is one of the most fundamental and enduring debates in American politics. Economics can be used to analyze the relative merits of government intervention in the economy in specific areas, but it cannot answer
Labonte, Marc
core +4 more sources
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Environmental Regulation: An Examination of John Locke’s Ordered Liberty and Government Intervention [PDF]
, 1991 Since the last financial crisis banks have been more restrictive about lending to companies, leading to companies seeking alternative funding. In this thesis we evaluate the Swedish market for property-related lending focusing on corporate bonds.
Hertéus, Robin, Hilmgård, Simon
core +2 more sources
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source