Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
COVIDThe COVID-19 pandemic has had profound impact, necessitating a deeper understanding of factors influencing virus transmission. The negative impacts have weakened the economy and changed billions of lives around the world.
Mohammad Meregan +4 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Transcriptional Regulation of Insulin-Like Growth Factor-I Receptor Gene Expression in Prostate Cancer Cells**This work was supported by V.A. Merit Review Program (to S.R.P.), DAMD 17–98-1–8540 (to J.L.W.), NIH DK-52683 (to S.R.P. and J.L.W.), and NIH DK-50810 (to C.T.R.). The content of this report does not necessarily represent the position or the policy of the United States government, and no official endorsement should be inferred. [PDF]
, 2001 Susan E. Damon +6 more
openalex +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Government regulation of private health insurance. [PDF]
Cochrane Database Syst Rev, 2021 Motaze NV +4 more
europepmc +1 more source
A Brief Review of Current and Proposed Federal Government Regulation of Assisted Reproduction Laboratories in the United States [PDF]
, 2002 Douglas T. Carrell, Deborah Cartmill
openalex +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Role of risk perception and government regulation in reducing over-utilization of veterinary antibiotics: Evidence from hog farmers of China. [PDF]
One Health, 2022 Si R, Yao Y, Liu X, Lu Q, Liu M.
europepmc +1 more source