Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Expanding Investment Opportunities Banking System Based on the use of Monetary Instruments Расширение инвестиционных возможностей банковской системы на основе использования инструментов денежно-кредитного регулирования [PDF]
Bìznes Inform, 2012 The paper investigates investment opportunities in the region's banking system and the system of measures of differentiation required reserves, depending on the nature of the transactions carried out by banks.
Zvarich Yelena I.
doaj
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Influence of Food Safety Concerns and Satisfaction with Government Regulation on Organic Food Consumption of Chinese Urban Residents. [PDF]
Foods, 2022 Chai D, Meng T, Zhang D.
europepmc +1 more source
Transcriptional Regulation of Insulin-Like Growth Factor-I Receptor Gene Expression in Prostate Cancer Cells**This work was supported by V.A. Merit Review Program (to S.R.P.), DAMD 17–98-1–8540 (to J.L.W.), NIH DK-52683 (to S.R.P. and J.L.W.), and NIH DK-50810 (to C.T.R.). The content of this report does not necessarily represent the position or the policy of the United States government, and no official endorsement should be inferred. [PDF]
, 2001 Susan E. Damon +6 more
openalex +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Evolutionary game analysis of environmental pollution control under the government regulation. [PDF]
Sci Rep, 2022 Zhou K, Wang Q, Tang J.
europepmc +1 more source
Molecular Oncology, EarlyView.Comprehensive cancer centre (CCCs) and CCCs of Excellence (CCCoE) integration in healthcare. Through outreach to surrounding community hospitals, CCCs enable wider access to top‐clinical cancer treatments and care, thereby facilitating the swift enrolment of patients into data‐rich clinical trials (PI‐initiated trials testing new concepts, drug ...
Anton Berns +4 more
wiley +1 more source
Environmental Regulation: An Examination of John Locke’s Ordered Liberty and Government Intervention [PDF]
, 1991 Since the last financial crisis banks have been more restrictive about lending to companies, leading to companies seeking alternative funding. In this thesis we evaluate the Swedish market for property-related lending focusing on corporate bonds.
Lasley, Jonathan G.
core +2 more sources
Government regulation of private health insurance. [PDF]
Cochrane Database Syst Rev, 2021 Motaze NV +4 more
europepmc +1 more source