Results 151 to 160 of about 529 (214)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

IT Security and IT Governance Alignment

Proceedings of the 3rd International Conference on Networking, Information Systems & Security, 2020
This paper review and align IT Security (ITS) and IT Governance (ITG) that would address ITS strategic and its operational issues. These issues if not addressed accordingly, would lead to a financial aftermath that would put the business at risk and jeopardize the organization's sustainability in both short and long run.
Norli Shariffuddin, Azlinah Mohamed
openaire   +1 more source

Securing e-Government

2004
This paper is engaged in research in security, peculiarities and implementations of security requirements within governmental structures. Based on three interaction points (citizen to government C2G, government to government G2G and government to citizen G2C) appropriate examples were chosen, security implementations analyzed and special attributes ...
Sonja Hof, Peter Reichstädter
openaire   +1 more source

Information Security Governance

Information Security Technical Report, 2001
Abstract “Directors have a responsibility to protect shareholder value. This responsibility applies just as stringently to valued information assets as it does to any other asset. Boards must recognise that securing that information is not just an investment; it is essential for survival in all cases and for many it can even create competitive ...
openaire   +1 more source

Demand for Government Securities

The Journal of Finance, 1969
THIS STUDY CONSTRUCTS a conceptual framework for analyzing commercial-bank, nonbank-financial, corporate, and household demand for government securities and presents empirical estimates of the model developed. The theoretical foundation of this study relies heavily on the theory of portfolio selection developed by Markowitz, Tobin, and Farrar, which ...
openaire   +1 more source

Government and Governance of Security

2018
At a time when Latin America is experiencing societal unrest from human rights violations, corruption and weak institutions Government and Governance of Security offers an insightful understanding for the modern steering of crime policies. Using Chile as a case study, the book delivers an untold account of the trade-offs between political, judicial and
openaire   +1 more source

THE RATE OF INTEREST ON GOVERNMENT SECURITIES

Science, 1902
exaly   +3 more sources

Security, Governance and Security Sector Governance

2011
The understanding of security has recently moved away from national security to include the consideration of a larger number of threats and additional objects of security. In parallel, changes occurred in governing, with growing importance of norms and rules coming from outside of the state and multi-actor participation in decision making and ...
openaire   +1 more source

Governing Security, Governing Through Security

2001
Most discussions about antiterrorism laws assume that the relation between "security" and "freedom" is a zero-sum game. Drawing on the large literature on the democratic provision of security and its governance, this article suggests that heavy-handed draconian methods are not always the best means to achieve citizen security - here distinguished from ...
openaire   +1 more source