Results 41 to 50 of about 1,108,976 (316)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Role of the Safeguarder in the Children's Hearings System [PDF]

open access: yes, 2017
The aims of this study were: 1. to identify and quantify the added value that safeguarders bring to decisions relating to children and young people in children’s hearings proceedings from the perspective of practitioners and professionals (including ...
Barry, Monica   +7 more
core  

Bilateral Control of Flexible Master-Slave Arms with Time-Varying Delay Affected by Contact Force from Obstacle

open access: yesSICE Journal of Control, Measurement, and System Integration, 2017
A bilateral control system for flexible master-slave arms with time-varying delay affected by contact force from an obstacle is considered in this study.
Masaharu Yagi, Yuichi Sawada
doaj   +1 more source

SYNOPTIC OBSERVATIONS OF CALVING EVENTS IN ANTARCTICA USING SPACEBORNE IMAGES [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2018
Iceberg calving is the detachment of ice from ice shelves or glaciers. Although calving is a natural phenomenon, an abnormal rate of calving can be a threat to ice shelves.
S. D. Jawak   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Local Government Excellence Programme prospectus – overview [PDF]

open access: yes, 2016
The 2015 New Zealand Local Government Survey found residents and businesses had a low awareness of the full services councils provide and the value they bring.
Local Government New Zealand
core  

Electronic communities in e-government system

open access: yesAspekti Publìčnogo Upravlìnnâ, 2020
The deepening digital transformation of society and the resulting changes in the organization of power have a significant impact on the process of creating electronic communities.
Nataliia Piskokha
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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