Results 81 to 90 of about 505,257 (335)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Time, Politics and Homelessness in Contemporary Japan [PDF]

open access: yes, 2017
Peer reviewedPublisher ...
Vij, Ritu
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Governing the Local? A Response to Kevin Stenson

open access: yesSocial Work and Society, 2008
Kevin Stenson's article offers a powerful argument for examining governmentality in particular local configurations rather than as relatively abstract and text-centred studies of changing mentalities and rationalities of rule.
John Clarke
doaj   +2 more sources

Whose Calculations? Which Rationalities?: Rationality of Governmentality and Irrationality of Risks in the Concept of Foucault

open access: yesСоциология власти
This article is dedicated to investigating rationality as one of the key characteristics of Michel Foucault's concept of governmentality and to related 30 contradictions inside and outside Foucauldian theory.
M. D. Belov
doaj   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

open access: yesFEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar   +3 more
wiley   +1 more source

Ethnographies of Neoliberal Governmentalities: from the neoliberal apparatus to neoliberalism and governmental assemblages

open access: yesFoucault Studies, 2014
This article is aimed at Foucauldian scholars and seeks to introduce them to ethnographic works that interrogate neoliberal governmentalities.  As an analytic category      ‘neoliberalism’ has over the last two decades helpfully illuminated connections ...
Michelle Brady
doaj   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

open access: yesFEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart   +4 more
wiley   +1 more source

Interpreting neoliberalism with Foucault and Lacan: Fantasy, depression and the entrepreneurial subjectivity [PDF]

open access: yesSociološki Pregled
The article is dedicated to the construction of a unique theoretical framework aimed at understanding the phenomenon of neoliberalism. In this regard, we primarily rely on the conceptual framework of the governmentality theory, which originates from the ...
Urošević Milan A.
doaj   +1 more source

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