Results 141 to 150 of about 872,770 (359)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Adams County Votes for President, 1804-2008

open access: yes, 2009
Adult male Europeans who were living in what is now Adams County, Pennsylvania, when York County was formed in 1749 could not vote to choose either their king or their governor.
Glatfelter, Charles H.
core  

Approval of Hassan and Legislature High, NH Supportive of Voter ID 7/31/13 [PDF]

open access: yes, 2013
New Hampshire residents approve of the job that Governor Maggie Hassan and the State Legislature are doing.
Survey Center, UNH
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Lynch Approval Ratings Slip Slightly, Jobs And Economy Top Concern 2/9/2010 [PDF]

open access: yes, 2010
Governor John Lynch job approval ratings in New Hampshire have dropped somewhat in recent months as economic concerns, and concerns about the state budget are the top problems on the minds of New Hampshire ...
Survey Center, UNH
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Benson and Lynch Tied in Race for NH Governor 10/05/2004 [PDF]

open access: yes, 2004
Democratic challenger John Lynch has pulled into a tie with incumbent Craig Benson in the race for New Hampshire governor. Benson is seen as better able to handle taxes and the cost of health care while voters think Lynch is better able to handle ...
Survey Center, UNH
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

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