Results 121 to 130 of about 61,865 (283)

Safety and Efficacy of Damoctocog Alfa Pegol in Previously Treated Children Aged 7 to < 12 Years With Severe Haemophilia A in the Phase 3, Open Label Alfa‐PROTECT Main Study

European Journal of Haematology, EarlyView.
ABSTRACT Background In the earlier PROTECT VIII Kids study (NCT01775618), damoctocog alfa pegol was efficacious for prevention and treatment of bleeds in children aged < 12 years with severe haemophilia A. Objective Assess the safety of damoctocog alfa pegol, including hypersensitivity and loss of efficacy (LoE) due to an immune response to ...
Margareth C. Ozelo, Matteo Luciani, Heidi Glosli, Kaan Kavakli, Nasrin Samji, Gregory C. Makris, Claudia Tueckmantel, Monika Maas Enriquez, Luciana C. Oliveira, Shveta Gupta, Mario Guillermo Arbesú, Mauro Davoli, Anthony K. C. Chan, Maria E. Mancuso   +13 more
wiley   +1 more source

Registration of Stillbirth After Early Fetal Death: A National Population‐Based Analysis

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
Ruth J. Matthews, K. Sruthi Vydyula, Ian D. Gallimore, Bradley N. Manktelow, Lucy K. Smith   +4 more
wiley   +1 more source

Comparative Effectiveness and Safety of PI‐Rd Triplets in Relapsed/Refractory Multiple Myeloma: INSIGHT‐MM Data Analysis

European Journal of Haematology, EarlyView.
Assessment of the comparative effectiveness and safety of three PI‐Rd triplets in relapsed/refractory multiple myeloma using data from the global, non‐interventional, observational INSIGHT‐MM study. ABSTRACT Objectives To assess the effectiveness/safety of three proteasome inhibitors (PIs), plus lenalidomide‐dexamethasone (Rd) triplet regimens, for the
Noemi Puig, Xavier Leleu, Hans C. Lee, Faith E. Davies, Roman Hájek, Vania Hungria, Michael A. Thompson, Gordon Cook, Jorge Vela Ojeda, Katja C. Weisel, Jesus G. Berdeja, Saad Z. Usmani, Argiris Symeonidis, Isabel Nascimento‐Ferreira, David Arthur, Lenka Mokrá, Kaili Ren, Dasha Cherepanov, Evangelos Terpos   +18 more
wiley   +1 more source

GPP estimation based on CatBoost and analysis of change driving factors in Shanxi Province, China

Scientific Reports
The gross primary productivity (GPP) of Shanxi Province, China, plays an important role in the carbon cycle of the Loess Plateau ecosystem. However, Shanxi Province lacks carbon flux stations, leading to imprecise GPP estimation results.
Yujie Li, Xuanguang Liu, Zhenchao Zhang, Jun Lang   +3 more
doaj   +1 more source

A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures

Epilepsia, EarlyView.
A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures. Abstract Objectives This randomized, double‐blind, placebo‐controlled study (NCT04557085), conducted in China, Japan, and the Republic of Korea, evaluated the efficacy and safety of ...
Sang Kun Lee, Peimin Yu, Eunyeong Choe, Louis Ferrari, Kyoung Heo, Seung Bong Hong, Zhen Hong, Koji Iida, Yong Heui Jeon, Jiwon Jung, Marc Kamin, Kensuke Kawai, Ji Hyun Kim, Myung Won Kim, Xiaorong Liu, Jungshin Park, William E. Rosenfeld, Takamichi Yamamoto, Dong Zhou, Suiqiang Zhu, Sunita N. Misra   +20 more
wiley   +1 more source

Early response rates with adjunctive cenobamate in uncontrolled focal seizures: Prospective analysis of a randomized, double‐blind, placebo‐controlled study in a multinational Asian population

Epilepsia, EarlyView.
Graphical representation of article highlights, including early response rates with adjunctive cenobamate. Abstract Objective To examine early responses to cenobamate therapy using prospective data from a dose–response study in Asian patients with focal seizures (YKP3089C035, C035) that employed a titration regimen starting at 12.5 mg/day.
Kensuke Kawai, Eunyeong Choe, Louis Ferrari, Kyoung Heo, Seung Bong Hong, Huapin Huang, Koji Iida, Yong Heui Jeon, Jiwon Jung, Marc Kamin, Ji Hyun Kim, Myung Won Kim, Sang Kun Lee, Songqing Pan, Jungshin Park, Pranoti Pradhan, William E. Rosenfeld, Huiqin Xu, Takamichi Yamamoto, Sunita N. Misra   +19 more
wiley   +1 more source

Clinical and Disease Burden of Patients with Generalized Pustular Psoriasis: A Review of Real-World Evidence

Dermatology and Therapy
Generalized pustular psoriasis (GPP) is a chronic, rare, and potentially life-threatening disease. There is limited understanding of patient characteristics in GPP and their correlation with disease progression or healthcare resource utilization.
Tina Bhutani, Aaron S. Farberg
doaj   +1 more source

The assessment of NPP/GPP ratio

Tree Physiology, 2020
Mathew Williams, Richard H Waring, Joe J Landsberg   +2 more
openaire   +2 more sources

Expanding the substrate scope of a bacterial monoterpene synthase for the production of sesquiterpenoid and diterpenoid products

The FEBS Journal, EarlyView.
We have converted the only known true bacterial monoterpene synthase, cineole synthase from Streptomyces clavuligerus (bCinS, C10 substrate), to a highly competent sesquiterpene synthase (C15) with a minimum number of rational mutations. By comparison with diterpene synthases (C20), we were then able to bestow diterpene synthase activity on bCinS. This
Nicole G. H. Leferink, Joshua N. Whitehead, Linus O. Johannissen, Nigel S. Scrutton   +3 more
wiley   +1 more source

Barriers to adoption of a personal health record in an ophthalmic setting: lessons from implementation of a Glaucoma Patient Passport

Clinical Ophthalmology, 2019
Imad Badran,1,2 Alice Bruynseels,1,3 Salim Khan,2 Freda Sii,1,3 Peter Shah1,3–51Ophthalmology Department, Queen Elizabeth Hospital Birmingham, Birmingham, UK; 2Department for Therapies and Public Health, Birmingham City University ...
Badran I, Bruynseels A, Khan S, Sii F, Shah P   +4 more
doaj