Results 71 to 80 of about 25,422 (300)

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Numerical optimization of the GPP Pharmaceutical Inspectorate [PDF]

, 2022
Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Chişinău, Republica MoldovaIntroducere. Eficiența sistemului de control farmaceutic (SCF) într-o mare măsură depinde de disponibilitatea unui număr optimal de farmaciști ...
Doroșchevici, Alina
core  

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

What factors influence the uptake of GPP (Green Public Procurement) practices? New evidence from an Italian survey [PDF]

Green Public Procurement (GPP) is becoming a cornerstone of environmental policies both at European Union and Member State level. Drawing upon a database of public authorities located in three Italian Regions, this paper assesses the determinants and ...
Marco Frey, Francesco Testa, Fabio Iraldo, Tiberio Daddi   +3 more
core  

The Circular Economy in European Union Supply Chains: A Literature Review

Sustainable Development, EarlyView.
ABSTRACT This research aims to analyze the implementation of the circular economy (CE) in European Union (EU) supply chains (SC), highlighting its potential to transform production systems and maximize resource efficiency while minimizing waste. Our study identifies the major trends and advancements in this field, focusing on the barriers that prevent ...
Luis Oswaldo Rodríguez‐Mañay, Inmaculada Guaita‐Pradas, Inmaculada Marques‐Perez   +2 more
wiley   +1 more source

Analysis of the Spatiotemporal Distribution Pattern of Mid-Tropospheric CO2 and Its Driving Forces over Central Asia During 2003–2011

Canadian Journal of Remote Sensing
Carbon dioxide (CO2), the major anthropogenic greenhouse gas, plays a critical role in climate change. Using Atmospheric Infrared Sounder (AIRS) CO2 retrievals and auxiliary datasets, this study investigated the spatiotemporal characteristics of mid ...
Liangzhong Cao, Xia Fang, Shihua Zhu, Chi Zhang, Shulei Jin, Zuoying Tu, Xiaojie Hou, Dongmei Zhao   +7 more
doaj   +1 more source

Complex multitrophic species interactions and fitness costs: Intricate consequences of jasmonate and salicylate induced plant defences

Journal of Animal Ecology, EarlyView.
This study reveals how long‐term activation of jasmonic and salicylic acid signalling reshapes arthropod communities and plant fitness across seasons. By showing that induced defences generate contrasting outcomes and cascading trade‐offs across trophic levels, it challenges the assumption that induced resistance is uniformly beneficial in natural ...
Mônica F. Kersch‐Becker, Guilherme P. Pinheiro, Thaís S. Schweller, Martin Pareja, Victoria M. Pocius, José R. Trigo, Gustavo Q. Romero   +6 more
wiley   +1 more source

Geraniales Phylogeny Poster (GPP)

, 2017
The Geraniales Phylogeny Poster (GPP) depicts the phylogenetic relationships between the five families of the order recognized here: Geraniaceae, Hypseocharitaceae, Vivianiaceae, Francoaceae, and Melianthaceae – down to the genus level – based on past and most recent research results.
Jeiter, Julius, Cole, Theodor C H, Hilger, Hartmut H   +2 more
openaire   +1 more source

Europe Gross Primary Productivity (GPP) Dataset 2018

, 2023
Europe Gross Primary Productivity (GPP) Dataset 2018 Product: Gross Primary Productivity (GPP) Year: 2018 Region: Europe Temporal Scale: 8 Days Spatial Resolution: 500 meters Method: Light-use-efficiency (LUE) approach. Referred Publication: https:
Subhajit Bandopadhyay, Jadu Dash, Booker Ogutu   +2 more
core   +1 more source

Assessment of Grades of Recommendations and Applicability of Royal College of Obstetricians and Gynaecologists Green‐Top Guidelines: A Cross‐Sectional Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Royal College of Obstetricians and Gynaecologists (RCOG) Green‐top Guidelines (GTGs) provide evidence‐based recommendations in women's health. Even where evidence is considered high quality, it is uncertain whether factors known to influence maternity outcomes are reflected in study design.
Anangsha Kumar, Alexandra Cocking, Megan Hall, James Morris, Srividhya Sankaran, Holly Lovell, Andrew Shennan, Kypros Nicolaides, Lisa Story   +8 more
wiley   +1 more source