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Tec regulates platelet activation by GPVI in the absence of Btk [PDF]
AbstractThe Tec family kinase Btk plays an important role in the regulation of phospholipase Cγ2 (PLCγ2) downstream of the collagen receptor glycoprotein VI (GPVI) in human platelets. Platelets also express a second member of this family, Tec; however, its function has not been analyzed.
Steve P. Watson +4 more
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FcRγ-Chain Signals in GPVI-Deficient Platelets.
Blood, 2005Abstract The receptor glycoprotein VI (GPVI) is required for hemostasis and collagen-induced platelet aggregation. GPVI and FcRγ-chain form a noncovalent signaling complex. Genetic ablation of murine FcRγ-chain prevents expression of GPVI, and immunodepletion of GPVI removes FcRγ chain from platelet membranes.
Carl W. Jackson +3 more
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GPVI and collagen: the final word?
Blood, 2022Alexandre Slater, Martine Jandrot-Perrus
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DAPT and GPVI: an antiplatelet triple threat
Journal of Thrombosis and Haemostasis, 2023Andrew, Rickenberg, Michael, Holinstat
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New role for the GPVI/FcRγ chain complex
Blood, 2006Comment on Inoue et al, page [1405][1] Previously thought to function only in collagen-induced platelet activation, Inoue and colleagues report that the GPVI/FcRγ chain complex is a crucial component in relaying activation signals following platelet exposure to the extracellular matrix ...
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GPVI-mediated activation cascade
Reactome - a curated knowledgebase of biological pathways, 2015openaire +2 more sources

