Results 161 to 170 of about 107,087 (251)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

How to give and receive 
feedback effectively. [PDF]

open access: yesBreathe (Sheff), 2017
Hardavella G   +4 more
europepmc   +1 more source

Inverse Design of Copolyamides via Sequence‐Sensitive Multifidelity Hybrid Models and Teacher–Student Genetic Algorithm

open access: yesMaterials Genome Engineering Advances, EarlyView.
A sequence‐sensitive multi‐fidelity hybrid modeling framework combined with a teacher‐student genetic algorithm enables the inverse design of copolyamides. The hybrid model balances prediction accuracy, sequence‑sensitivity, and computational cost. A two‑tier genetic algorithm can efficiently identify the monomer structures and ratios of copolyamides ...
Sheng Chen   +8 more
wiley   +1 more source

Optimal‐Control 19F PROJECT Improves the Reliability of CPMG‐Derived Relaxation Rates

open access: yesMagnetic Resonance in Chemistry, EarlyView.
PROJECT with seedless optimal control pulses for 19F‐based protein‐ligand interaction screenings allows for a lower error in R2 estimates than those obtained with CPMG for J‐coupled fluorine signals and is indistinguishable from CPMG when the coupling is negligible, at the price of a modest reduction in SNR.
Marco Schiavina   +2 more
wiley   +1 more source

How can children and young people have a voice in urban treescapes?

open access: yesPeople and Nature, EarlyView.
Abstract Scientific understanding of climate change has, to date, failed to result in sufficient action. This paper proposes that a deficit model of top‐down learning and dissemination in relation to public engagement with science may be part of the problem, particularly when considering the attitudes, values and empowerment of children and young ...
Simon Carr   +10 more
wiley   +1 more source

Learning Based Segmentation of CT Brain Images: Application to Postoperative Hydrocephalic Scans. [PDF]

open access: yesIEEE Trans Biomed Eng, 2018
Cherukuri V   +5 more
europepmc   +1 more source

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