Results 231 to 240 of about 30,006 (292)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Explainable Hybrid Deep Learning Framework Integrating MobileNetV2, EfficientNetV2B0, and KNN for MRI-Based Brain Tumor Classification. [PDF]

Cell Mol Neurobiol
Adamu MJ, Qiang L, Nyatega CO, Fahad M, Younis A, Jabire AH, Zakariyya RS, Kawuwa HB.   +7 more
europepmc   +1 more source

From Green to Grad School

The ASHA Leader, 2017
openaire   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Deciding How Much to Trust AI for Teaching and Assessment. [PDF]

J Grad Med Educ
Preiksaitis C.
europepmc   +1 more source

Prior-aligned frequency-domain explanations for heart sound classification: a scale-consistent attribution approach. [PDF]

Front Artif Intell
Sun Q, Li Y, Javadov A, Wu X, Schuller BW.   +4 more
europepmc   +1 more source

Interpretable two-stage deep learning for pediatric obstructive sleep apnea diagnosis using lateral cephalograms. [PDF]

Front Pediatr
Zhang J, Tan J, Tong X, Wang H, Zhao Y, Song J, Liu Y.   +6 more
europepmc   +1 more source

Development of a diagnostic model for esophageal achalasia assessed by esophageal high-resolution manometry using artificial intelligence. [PDF]

Exp Ther Med
Tabuchi M, Nakao Y, Minami H, Inomata H, Shiota J, Akashi T, Hashiguchi K, Kitayama M, Matsushima K, Yamaguchi N, Akazawa Y, Miyaaki H.   +11 more
europepmc   +1 more source

Following the Grain. [PDF]

J Grad Med Educ
Saddawi-Konefka D.
europepmc   +1 more source