Results 31 to 40 of about 3,791 (280)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Research on Forest Fire Smoke and Cloud Separation Method Based on Fisher Discriminant Analysis

Remote Sensing
In remote sensing monitoring of forest fires, smoke and clouds exhibit similar spectral characteristics in satellite imagery, which can easily lead to clouds being misjudged as smoke. This incorrect discrimination may result in missed detections or false
Jiayi Zhang, Jun Pan, Yehan Sun, Lijun Jiang, Kaifeng Liu   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

La représentation cartographique des phénomènes continus dans l'espace géographique [PDF]

, 1988
Les problèmes soulevés par la representation des phénomènes continus sont analysés à travers l'exemple de la densité de population de l'Île-de-France.
Thierry SAINT-GERAND, Éliane LETERRIER, Françoise PIROT   +2 more
core   +2 more sources

Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine

Journal of Lipid Research, 2001
The current study used the human Caco-2 cell line and mouse intestine to explore the topology of expression of the class B type I scavenger receptor (SR-BI) in intestinal cells.
Sheng F. Cai, R. Jason Kirby, Philip N. Howles, David Y. Hui   +3 more
doaj   +1 more source

Aggregate gradation effect on the mechanical properties of asphalt mixtures [PDF]

, ,The issue of road deterioration in Mosul, Iraq, has become a matter of concern for local communities. The instability of road surfaces under the stress of vehicular traffic necessitates significant intervention to mitigate and manage this problem ...
Putra Jaya, Ramadhansyah, Zaid Hazim, Al-Saffar, M abed, Jasim, Imad Dawood, Sulaiman   +3 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Study on Gradation Improvement of Gravel and Sand for Surface Layer of Railway Subgrade by Blending Method [PDF]

American Journal of Traffic and Transportation Engineering, 2019
As the direct foundation of the track, the surface layer of high-speed railway subgrade bed is one of the important parts of the subgrade. Its main function is to transmit and spread the vertical load of the upper ballast bed and the vehicle dynamic load to maintain the long-term stability of the subgrade bed surface.
openaire   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source