Results 71 to 80 of about 4,096,125 (206)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Programming Structural Symmetry and Emission in Low‐Dimensional Hybrid Perovskites via Time and Temperature

Advanced Science, EarlyView.
We demonstrate programmable structural symmetry and emission in benzylammonium‐based low‐dimensional hybrid perovskites. Continuous shaking transforms orthorhombic platelets into a lower‐symmetry monoclinic phase with broadband emission, whereas thermal activation drives the reverse pathways toward a higher‐symmetry configuration resembling the ...
Luiz G. Bonato, Sirous Khabbaz Abkenar, Balaji Dhanabalan, Quentin Evrard, Luca Goldoni, Sergio Marras, Giorgio Divitini, Milena P. Arciniegas   +7 more
wiley   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Tilted Gaussian Beams Multiplexer for Graded-Index Multimode Fiber in Data-Centers Interconnections

IEEE Photonics Journal, 2015
In recent years, there has been an explosive growth of data traffic in data-center interconnections. A significant amount of the installations within data centers are graded-index multimode fibers (GI-MMFs).
N. Sheffi, D. Sadot
doaj   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

CW‐Pumped Amplified Spontaneous Emission From Thermally Evaporated CsPbBr3 Films

Advanced Science, EarlyView.
Thermally evaporated CsPbBr3 thin films sustain amplified spontaneous emission from short‐pulse toward quasi‐continuous‐wave excitation. Time‐resolved spectroscopy, controlled excitation, and substrate engineering reveal how excitation duration governs optical‐gain stability.
Yuliia Kominko, Willem Verheijen, Gabriele Rainò, Simon C. Boehme, Maksym V. Kovalenko, Sergii Yakunin   +5 more
wiley   +1 more source

Artificial intelligence based prediction of refractive index profile of graded refractive index optical fiber

ICT Express
This research presents a deep neural network (DNN) approach for predicting the refractive index profile in graded-index multimode fibers (GRIN MMFs).
Seung-Yeol Lee, Hyuntai Kim
doaj   +1 more source

Reconfigurable Design and Optimization‐Based Control of an Integrated Leg‐Arm Robot for Space Applications With an Underactuated Body

Advanced Intelligent Systems, EarlyView.
A quadrupedal integrated leg‐arm robot with an underactuated reconfigurable body is developed. By using a Sarrus mechanism as the body, the robot enables reconfiguration through its supporting limbs, achieving mode switching without additional actuators.
Xinghan Zhuang, Kun Xu, Shutao Wu, Haoyuan Liu, Bochao Song, Jiawei Chen, Peijin Zi, Tao Zhang, Xilun Ding   +8 more
wiley   +1 more source

Biomimetic Nanofiber Scaffold Coated With Acellular Matrices for Uterine Myometrial Tissue Engineering

Advanced NanoBiomed Research, EarlyView.
Schematic representation of acellular matrix generation from human uterine fibroblast cells, coating on polycaprolactone electrospun nanofibers, and subsequent in vitro and in vivo characterization. A tissue‐engineered scaffold tailored for uterine myometrium‐specific regeneration is designed. The electrospinning technique was used to fabricate aligned
Srividya Hanuman, Shripad S. Hebbar, Rishikesh Balvalli, Manasa Nune   +3 more
wiley   +1 more source

High power high repetition rate supercontinuum generation in graded-index multimode fibers

, 2017
Graded-index multimode fibers can handle high average powers and feature unique nonlinear dynamics due to spatio-temporal evolution of the light inside.
Uğur Teğin (14417979), Bülend Ortaç (3974282)   +1 more
core   +1 more source