Results 151 to 160 of about 18,171,804 (281)
Responsibility Without Free Will: A Graded Neurocognitive Model
A graded neurocognitive model of responsibility that rejects metaphysical free will and reconceptualizes responsibility as a continuous function of cognitive control, affective integration, and predictive stability under contextual constraints. Drawing on neuroscience, neuropsychology, and predictive processing, the paper argues that responsibility is ...
openaire +2 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
PENGEMBANGAN INSTRUMEN DIAGNOSIS KESULITAN BELAJAR PADA PEMBELAJARAN KIMIA DI SMA
Jurnal Penelitian dan Evaluasi Pendidikan, 2015 Tujuan penelitian ini untuk: (1) mengembangkan instrumen ordered multiple-choice untuk diagnosis kesulitan belajar Stoikiometri kelas X, (2) menetapkan karakteristik dari instrumen, dan (3) membuat profil diagnostik peserta didik sebagai laporan yang ...
Sri Yamtinah, Budiyono Budiyono
doaj
Graded rings and graded Grothendieck groups
, 2016 This study of graded rings includes the first systematic account of graded Grothendieck ...
Hazrat, Roozbeh +1 more
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
ltm: An R Package for Latent Variable Modeling and Item Response Analysis [PDF]
The R package ltm has been developed for the analysis of multivariate dichotomous and polytomous data using latent variable models, under the Item Response Theory approach.
Dimitris Rizopoulos
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source