Results 151 to 160 of about 21,796,219 (281)

Influence of Material and Geometric Gradation on the Blast Response of Metallic Honeycomb Sandwich Structures: A Numerical Study

Journal of Engineering
Lightweight and high-strength structures are increasingly required to mitigate the effects of blast loading. This study presents a numerical investigation of the dynamic response of honeycomb sandwich panels with different material and geometric ...
Md. Ashraful Islam, Sajjad Hossain, Fahim Ahamed Shanto, Md. Abdul Hasib, Md. Mahbubur Rahman   +4 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Responsibility Without Free Will: A Graded Neurocognitive Model

A graded neurocognitive model of responsibility that rejects metaphysical free will and reconceptualizes responsibility as a continuous function of cognitive control, affective integration, and predictive stability under contextual constraints. Drawing on neuroscience, neuropsychology, and predictive processing, the paper argues that responsibility is ...
openaire   +2 more sources

Character assessment reimagined: an IRT-based graded response model for honesty and discipline

Purpose: to develop and validate an IRT-based graded response model (GRM) instrument for assessing honesty and discipline among junior secondary school students.
Kristina Luturdas, Yakob Luturmas
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

PENGEMBANGAN INSTRUMEN DIAGNOSIS KESULITAN BELAJAR PADA PEMBELAJARAN KIMIA DI SMA

Jurnal Penelitian dan Evaluasi Pendidikan, 2015
Tujuan penelitian ini untuk: (1) mengembangkan instrumen ordered multiple-choice untuk diagnosis kesulitan belajar Stoikiometri kelas X, (2) menetapkan karakteristik dari instrumen, dan (3) membuat profil diagnostik peserta didik sebagai laporan yang ...
Sri Yamtinah, Budiyono Budiyono
doaj  

The unique correspondence of the item response function and item category response functions in polytomously scored item response models

item response theory, polytomous item, partial credit model, generalized partial credit model, graded response model, invariance, ordered categories,
Hua-Hua Chang, John Mazzeo
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

13. Lecture (23.01.2017): Graded Response Model (GRM) with logit and probit link functions

, 2017
Topics: Graded Response Model (GRM) with logit and probit link functions, Basic assumptions and their implications for the category probabilities, Thresholds and discrimination parameters in these models, Application of the probit ...
Multimediazentrum, Steyer, Rolf
core