Results 21 to 30 of about 24,533 (190)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Computing j-multiplicity [PDF]

open access: yes, 2008
The j-multiplicity is an invariant that can be defined for any ideal in a Noetherian local ring $(R, m)$. It is equal to the Hilbert-Samuel multiplicity if the ideal is $m$-primary. In this paper we explore the computability of the j-multiplicity, giving
Nishida, Koji, Ulrich, Bernd
core   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

open access: yesArthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh   +5 more
wiley   +1 more source

The uniform face ideals of a simplicial complex [PDF]

open access: yes, 2013
We define the uniform face ideal of a simplicial complex with respect to an ordered proper vertex colouring of the complex. This ideal is a monomial ideal which is generally not squarefree.
Cook II, David
core  

The cone of Betti diagrams of bigraded artinian modules of codimension two

open access: yes, 2010
We describe the positive cone generated by bigraded Betti diagrams of artinian modules of codimension two, whose resolutions become pure of a given type when taking total degrees.
Fløystad, Gunnar   +2 more
core   +1 more source

Packaging of Macroscopic Material Payloads: Needs, Challenges, Concepts, and Future Directions

open access: yesAdvanced Engineering Materials, EarlyView.
This review introduces a unified framework that decomposes any macroscopic packaging system into the payload, packaging material, and packaging strategy and combines them into a conceptual packaging equation: packaging strategy = payload + packaging material.
Venkata S. R. Jampani, Manos Anyfantakis
wiley   +1 more source

Towers of MU-algebras and the generalized Hopkins-Miller theorem

open access: yes, 2002
Our results are of three types. First we describe a general procedure of adjoining polynomial variables to $A_\infty$-ring spectra whose coefficient rings satisfy certain restrictions.A host of examples of such spectra is provided by killing a regular ...
Lazarev, A.
core   +1 more source

Application of Raman and Photoluminescence Spectroscopy to MgO‐C Refractories

open access: yesAdvanced Engineering Materials, EarlyView.
Visible to near infrared luminescence of MgO is studied on MgO‐C bricks and nominally pure MgO powder, with focus on two similar sharp high‐intensity signals, at 699 and 871 nm, each surrounded by symmetrical sidebands. The nature of these sidebands is investigated by temperature‐dependent spectroscopic measurements, confirming phonon involvement by ...
Julia Richter   +5 more
wiley   +1 more source

Investigation of Oxygen‐Free Wetting Behavior of Aluminum on Copper via Molecular Dynamics Simulations and Experiments

open access: yesAdvanced Engineering Materials, EarlyView.
The wettability of aluminum droplets (Al) on different copper substrates (Cu), where liquid Al spreads on solid Cu surfaces to form a liquid–solid interface, is studied numerically and experimentally. The experimental and numerical results show good agreement in the fast‐spreading regime.
Shan Lyu   +8 more
wiley   +1 more source

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