Results 251 to 260 of about 914,879 (290)

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

A transparent AI assurance and benchmarking framework for EEG seizure detection on TUSZ seeded with a reproducible gradient-boosting ensemble. [PDF]

Sci Rep
Zabihi M, Gilmore EJ, Ding K, Rosenthal ES.   +3 more
europepmc   +1 more source

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Advanced Science, EarlyView.
GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng   +11 more
wiley   +1 more source

Machine learning optimization of obstructive sleep apnea screening: development and validation of a gradient boosting prediction model with a clinical implementation framework. [PDF]

Front Med (Lausanne)
Liu T, Que L, Bai W, Yao H.
europepmc   +1 more source

Comparing gradient boosting and neural networks in the prediction of intersecting genes in gingival epithelial immunity. [PDF]

J Indian Soc Periodontol
Ardila CM, Anegundi RV, Puttu G, Ayyachamy S, Yadalam PK.   +4 more
europepmc   +1 more source

From point to probabilistic gradient boosting for claim frequency and severity prediction. [PDF]

Eur Actuar J
Chevalier D, Côté MP.
europepmc   +1 more source

Predicting outcomes of nonsurgical retreatment with artificial intelligence: A multicenter retrospective study using logistic regression, random forest, and extreme gradient boosting. [PDF]

J Conserv Dent Endod
Muskan S, Sambandam TV, Solete P, Rossi-Fedele G, Spagnuolo G, Teja KV, Scolavino S, Armogida NG.   +7 more
europepmc   +1 more source

Investigating the association between the food inflammation scores of individuals and stroke in adults: an extreme gradient boosting machine learning model interpreted with shapley additive explanations. [PDF]

J Health Popul Nutr
Yan Z, Luo K, Yang Q, Liu X, Zhao H, Gao Y, Zhang Q, Mu J.   +7 more
europepmc   +1 more source

Importance of Flow Metrics on Modeling Macroinvertebrate Community in Dammed Rivers: An Approach With Optimized Gradient Boosting. [PDF]

Ecol Evol
Nukazawa K, Tanaka R, Mineda H.
europepmc   +1 more source