Results 51 to 60 of about 2,551,566 (242)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Royal Society Open Science, 2021 We present two different methods to estimate parameters within a partial differential equation model of cancer invasion. The model describes the spatio-temporal evolution of three variables—tumour cell density, extracellular matrix density and matrix ...
Yunchen Xiao +2 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Data filtering based stochastic gradient algorithms for multivariable CARAR-like systems
Mathematical Modelling and Analysis, 2013 This paper considers identification problems for a multivariable controlled autoregressive system with autoregressive noises. A hierarchical generalized stochastic gradient algorithm and a filtering based hierarchical stochastic gradient algorithm are ...
Dongqing Wang, Tong Shan, Rui Ding
doaj +1 more source
Estimating Parameters for Extension of Burr Type X Distribution by Using Conjugate Gradient in Unconstrained Optimization [PDF]
Kirkuk Journal of Science, 2019 The Conjugate gradient method used to estimate the parameter of Marshall-Olkin Exponentiated Burr Type X distribution (MOEBX). The proposed distribution MOEBX based on the work by (Marshall–Olkin 1997).
Zeyad Abdullah +3 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Board of Estimate and Apportionment, 1/29/1937 [PDF]
, 1937 True copy of a resolution adopted by the Board of Estimate and Apportionment allowing $400,000 of supplemental funds for the new Brooklyn College construction and ...
Board of Estimate and Apportionment
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Coarse-grained gyrokinetics for the critical ion temperature gradient in stellarators
Physical Review Research, 2022 We present a modified gyrokinetic theory to predict the critical gradient that determines the linear onset of the ion temperature gradient (ITG) mode in stellarator plasmas.
G. T. Roberg-Clark +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source