Results 81 to 90 of about 1,150,989 (314)

Exact gradient methods with memory. [PDF]

Optim Methods Softw, 2022
Florea MI.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Stochastic proximal gradient methods for nonconvex problems in Hilbert spaces. [PDF]

Comput Optim Appl, 2021
Geiersbach C, Scarinci T.
europepmc   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Iterated Ritz and conjugate gradient methods as solvers in constrained form-finding: A comparison. [PDF]

Heliyon, 2021
Šamec E, Gidak P, Fresl K.
europepmc   +1 more source

Controllability maximization of large-scale systems using projected gradient method [PDF]

, 2020
Kazuhiro Sato, Akiko Takeda
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Bilateral fusion low‐light image enhancement with implicit information constraints

IET Image Processing
Research on low‐light image enhancement focuses on improving image quality in dim conditions. Recently, deep learning has driven significant advancements, with many studies using neural networks to enhance low‐light images. However, most focus on complex
Jiahui Zhu, Shengbo Sang, Aoqun Jian, Le Yang, Luxiao Sang, Yang Ge, Rihui Kang, LiuWei Yang, Lei Tao, RunFang Hao   +9 more
doaj   +1 more source

Stochastic quasi-gradient methods: variance reduction via Jacobian sketching. [PDF]

Math Program, 2021
Gower RM, Richtárik P, Bach F.
europepmc   +1 more source

Optimizing Solution-Samplers for Combinatorial Problems: The Landscape of Policy-Gradient Methods [PDF]

, 2023
Constantine Caramanis, Dimitris Fotakis, Alkis Kalavasis, Vasilis Kontonis, Christos Tzamos   +4 more
openalex   +1 more source