Results 171 to 180 of about 7,425,127 (300)

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Case Report: Intra-articular injection of tocilizumab for arthritis treatment in chronic graft-vs.-host disease. [PDF]

Front Pediatr
Xie M, Liu Q, Yuan H, Chen Y, Zou X, Zhang Z, Zhong B, Zeng H, Zeng H.   +8 more
europepmc   +1 more source

Implantable electrochemical sensors for continuous blood monitoring

FlexMat, EarlyView.
Implantable electrochemical sensors enable direct, in situ, and continuous blood monitoring, shifting diagnosis from population‐based averages to dynamic, individualized analysis. This review systematically examines the influence of the unique blood properties on sensor design.
Kuangyi Zou, Yuanzhen Wang, Haidong Wang, Ye Zhang   +3 more
wiley   +1 more source

Influence of daytime of allogeneic stem cell transplantation on incidence of acute graft vs. host disease: a retrospective analytical cohort study. [PDF]

Bone Marrow Transplant
Wilcken H, Kaier K, Meyer T, Waterhouse M, Gräßel L, Duque-Afonso J, Marks R, Wäsch R, Finke J, Zeiser R, Maas-Bauer K, Wehr C.   +11 more
europepmc   +1 more source

The Role of Extracellular Vesicles (EVs) in Chronic Graft vs. Host Disease, and the Potential Function of Placental Cell-Derived EVs as a Therapeutic Tool. [PDF]

Int J Mol Sci, 2023
Zavaro M, Dangot A, Bar-Lev TH, Amit O, Avivi I, Ram R, Aharon A.   +6 more
europepmc   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Severe Hypertriglyceridemia in a Patient Treated With Sirolimus for Graft-vs-Host Disease Prophylaxis. [PDF]

JCEM Case Rep
Criner K, Student J, Arkin J, Carp J, Sokoloff S.   +4 more
europepmc   +1 more source

Interpretable Machine Learning Model for Fungal Infection Prediction: A Real‐World Study

Health Care Science, EarlyView.
Our study successfully developed and validated a machine learning model based on large‐scale electronic health record data to predict the risk of fungal infections in hospitalized patients. Through a Streamlit‐powered web platform, the model was seamlessly embedded into clinical workflows, completing the full pipeline from model construction to real ...
Jinru Yang, Shuqi Pan, Tao Luo, Bingzheng Zhang, Bilong Feng, Ying Wang   +5 more
wiley   +1 more source

Prevention of acute graft-vs.-host disease by targeting glycolysis and mTOR pathways in activated T cells. [PDF]

Exp Ther Med, 2022
Zhou RQ, Wang X, Ye YB, Lu B, Wang J, Guo ZW, Mo WJ, Yang Z, Srisuk P, Yan LP, Xu XJ.   +10 more
europepmc   +1 more source

Craniofacial Resection for Advanced Cutaneous Squamous Cell Carcinoma: Results From the 2nd International Collaborative Case‐Series

Head &Neck, EarlyView.
ABSTRACT Background Robust outcome data for anterior skull base cutaneous squamous cell carcinoma (cSCC) are limited, particularly as emerging therapies reshape management. We evaluated survival and prognostic factors following craniofacial resection. Methods Retrospective multi‐institutional case‐series (1995–2015) of patients who underwent skull base
Michael J. C. Schachtel, Benedict J. Panizza, James J. Bowman, Catherine Barnett, Cristina Valero, Ian Ganly, Snehal G. Patel, Helena Levyn, Dauren Adilbay, Alana Eagan, Marc A. Cohen, Lillian A. Boe, Junting Zheng, Mithat Gonen, Prathamesh Pai, Paolo Castelnuovo, Fang Ju Gao, Cesare Piazza, Piero Nicolai, Luiz P. Kowalski, Ronaldo N. Toledo, Claudio Cernea, Sergio Goncalves, Dan M. Fliss, John R. de Almeida, Ian Witterick, Philippe Herman, Walter Fontanella, Gregorio Sanchez Aniceto, Alvaro Rivero Calle, Sefik Hosal, Serdar Ozer, Subramania Iyer, Richard J. Harvey, C. Rene Leemans, Jan‐Jaap Hendrickx, Marcelo Figari, Luis Boccalatte, Ken Ichi Nibu, Peter Clarke, Catherine Rennie, Yiming Zhu, Rodney J. Schlosser, Fernando L. Dias, Zoukaa Sargi, Shahzada Ahmed, Wojciech Golusinski, Se Heon Kim, Shirley Y. Su, Shaan M. Raza, Franco DeMonte, Ehab Hanna, Jatin P. Shah   +52 more
wiley   +1 more source