Results 31 to 40 of about 5,921,684 (304)

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Impact of tacrolimus trough level variability on graft outcomes in low-immunological risk kidney transplantation

Renal Failure
Tacrolimus is the foundation of maintenance immunosuppression post renal transplantation, but its small therapeutic index and intra-patient variability (IPV) can affect the graft prognosis.
Ahmed Fayed, Moataz Fatthy, Heba Wagdy, Fadia Moris Bolis, Hany Hammad, Karim M. Soliman   +5 more
doaj   +1 more source

A study to evaluate the effect of ratio of donor kidney weight to recipient body weight on renal graft function

Urology Annals, 2014
Aim and Objectives: To study the effect of the ratio of donor kidney weight (dkw) to recipient body weight (rbw) on short and long term graft function in live donor kidney transplant patients. Materials and Methods: It was a prospective study of 79 live
Tanveer Iqbal Dar, Vipin Tyagi, Mrinal Pahwa, Sudhir Chada, Harsh Jauhari, Nikhil Sharma   +5 more
doaj   +1 more source

Introduction of the Grayscale Median for Ultrasound Tissue Characterization of the Transplanted Kidney

Diagnostics, 2021
Ultrasound examination is advised for early post-kidney transplant assessment. Grayscale median (GSM) quantification is novel in the kidney transplant field, with no systematic assessment previously reported. In this prospective cohort study, we measured
Camilo G. Sotomayor, Stan Benjamens, Hildebrand Dijkstra, Derya Yakar, Cyril Moers, Stephan J. L. Bakker, Robert A. Pol   +6 more
doaj   +1 more source

Older liver graft transplantation, cholestasis and synthetic graft function [PDF]

Transplant International, 2005
Older liver grafts are often discarded because of conservative selection criteria. We report on our clinical experience with graft-age related outcome. Patients transplanted with livers older than 70 years (70.2-80.2 years, n = 38) were compared with controls transplanted with livers younger than 70 years. Pairs were matched for age, gender, indication
Dietmar, Borchert, Matthias, Glanemann, Martina, Mogl, Jan M, Langrehr, Peter, Neuhaus   +4 more
openaire   +2 more sources

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Gene Transfer of Calcitonin Gene-Related Peptide Inhibits Macrophages and Inflammatory Mediators in Vein Graft Disease [PDF]

, 2008
Vein graft disease is a chronic inflammatory disease and limits the late results of coronary revascularization. Calcitonin gene-related peptide (CGRP) inhibits macrophages infiltrated and inflammatory mediators, we hypothesized that transfected CGRP gene
Jian Zhuang, Hongsui Wu, Shiliang Chen, Jian Su, Yuhui Zheng, Xiaoning Zhang, Jianguang Chen, Huanxin Yang, Zhihong Chen   +8 more
core  

Distribution of index values for delayed graft function.

, 2018
Distribution of index values for delayed graft function.
Lioe-Fee de Geus-Oei (715744), Andor W. J. M. Glaudemans (4989905), Stan Benjamens (4989908), Robert A. Pol (4989902), Stefan P. Berger (4989899), Riemer H. J. A. Slart (3622058), Aiko P. J. de Vries (404823)   +6 more
core   +1 more source

Donor and Recipient Polygenic Risk Scores Influence Kidney Transplant Function

Transplant International
Kidney transplant outcomes are influenced by donor and recipient age, sex, HLA mismatch, donor type, anti-rejection medication adherence and disease recurrence, but variability in transplant outcomes remains unexplained.
Kane E. Collins, Kane E. Collins, Kane E. Collins, Edmund Gilbert, Edmund Gilbert, Vincent Mauduit, Katherine A. Benson, Katherine A. Benson, Elhussein A. E. Elhassan, Elhussein A. E. Elhassan, Conall O’Seaghdha, Conall O’Seaghdha, Claire Hill, Amy Jayne McKnight, Alexander P. Maxwell, Peter J. van der Most, Martin H. de Borst, Weihua Guan, Pamala A. Jacobson, Ajay K. Israni, Brendan J. Keating, Graham M. Lord, Salla Markkinen, Ilkka Helanterä, Kati Hyvärinen, Jukka Partanen, Stephen F. Madden, Matthew B. Lanktree, Sophie Limou, Gianpiero L. Cavalleri, Gianpiero L. Cavalleri, Gianpiero L. Cavalleri, Peter J. Conlon, Peter J. Conlon   +33 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source