Results 181 to 190 of about 244,724 (294)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Evidence for a Clinically Meaningful Effect of no-Touch Harvesting Technique on Vein Graft Patency-A Bayesian Reanalysis of the SWEDEGRAFT Trial. [PDF]

Eur J Cardiothorac Surg
Sartipy U, Heuts S, James SK.
europepmc   +1 more source

Association of anaesthesia technique with 30-day primary graft patency after open lower limb revascularization: retrospective cohort study. [PDF]

BJS Open, 2022
Ke JXC, Flexman AM, Schwarz SKW, MacDonald S, Prabhakar C.   +4 more
europepmc   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Evaluation of Clinical Outcomes and Graft Patency Following Venous Resection and Vascular Reconstruction Using a Recanalized Ligamentum Teres Hepatis Graft in Pancreaticoduodenectomy. [PDF]

Ann Surg Oncol
Zhu WT, Liu ZW, Wei Q, Zhang F, Ji HB, Cui JY, Chen QP.   +6 more
europepmc   +1 more source

Performance Estimation and Ex Vivo Validation of Untethered Magnetic Robots in Soft Tissue

Advanced Science, EarlyView.
This study presents an empirical model that quantitatively predicts the step‐out frequency of screw‐type untethered magnetic robots (UMRs) in soft viscoelastic environments, including ex vivo brain tissue. By integrating key parameters into a dimensionless framework, the model enables estimation of robot performance across a range of biological ...
Leendert‐Jan W. Ligtenberg, Thijs J. van der Burg, Stijn Y. Kolkman, Santiago Saavedra Castano, David Fernandez Rivas, Anke Klingner, Roger M. L. M. Lomme, Lucas S. Joziasse, Dorothee Wasserberg, H. Remco Liefers, Doron Ben Ami, Udi Sadeh, Oded Shoseyov, Giulio Dagnino, Pascal Jonkheijm, Jurgen J. Fütterer, Stefano Stramigioli, J. Frank W. Nijsen, Michiel C. Warlé, Islam S. M. Khalil   +19 more
wiley   +1 more source

Successful Long-Term Outflow Graft Patency Restoration With a Stent-Graft Implantation in an LVAD Recipient. [PDF]

JACC Case Rep
Biełka A, Hawranek M, Walas R, Wilczek K, Gąska M, Kalinowski M, Głowacki J, Przybyłowski P.   +7 more
europepmc   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Evaluation of evolocumab on saphenous vein graft patency following coronary artery bypass graft surgery in people living with and without diabetes in the NEWTON-CABG CardioLink-5 trial. [PDF]

Diabetes Obes Metab
Teoh H, Verma S, Mancini GBJ, Quan A, Szarek M, Elituv R, Verma M, Misner E, Krishnaraj A, Jüni P, Koren MJ, Nicholls SJ, Bhatt DL, Mazer CD, Leiter LA.   +14 more
europepmc   +1 more source

Factors associated with long-term graft patency after lower extremity arterial bypasses. [PDF]

Ann Surg Treat Res, 2021
Jung KS, Heo SH, Woo SY, Park YJ, Kim DI, Kim YW.   +5 more
europepmc   +1 more source