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Syngeneic Graft-vs-Host Disease
Archives of Dermatology, 1987Graft-vs-hostD) can be a lethal complication of bone marrow transplantation. The acute form of the disease most often occurs by day 60 after transplant and may affect any or all of three major target organs, namely, skin, liver, and gastrointestinal ointestinal tract.1y ute GVHD terized by a dermatitis that begins as a pruritic macular exanthem on the ...
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Life-threatening graft-vs-host disease
Clinics in Dermatology, 2005Hematopoietic stem cell transplant (SCT) is considered standard therapy for a variety of malignant and nonmalignant diseases. Graft-versus-host disease (GVHD) still represents today a major complication of hematopoietic SCT. Two types of GVHD have traditionally been recognized on the basis of the time of onset following transplantation, distinct ...
Erich, Vargas-Díez +3 more
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2000
The transplantation of healthy hematopoietic stem cells into a patient with aplastic anemia or leukemia is potentially curative therapy, but the development of acute graftvs-host disease (GVHD), which often occurs even when the donor and recipient are siblings fully matched at the human leukocyte antigen (HLA) loci, significantly limits survival.The ...
Thomas R. Spitzer, Robert Sackstein
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The transplantation of healthy hematopoietic stem cells into a patient with aplastic anemia or leukemia is potentially curative therapy, but the development of acute graftvs-host disease (GVHD), which often occurs even when the donor and recipient are siblings fully matched at the human leukocyte antigen (HLA) loci, significantly limits survival.The ...
Thomas R. Spitzer, Robert Sackstein
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Bone Marrow Transplantation, 2005
JLM Ferrara, KR Cooke and HJ Deeg (eds) Third edition, 2005. Marcel Dekker, New York, NY, USA, ISBN: 0-8247-5472-7, 645pp.
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JLM Ferrara, KR Cooke and HJ Deeg (eds) Third edition, 2005. Marcel Dekker, New York, NY, USA, ISBN: 0-8247-5472-7, 645pp.
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Pathologie-biologie, 2006
Graft vs host disease is a serious immunological complication of allogeneic haematopoietic cell transplantation, leading to a significant morbidity and mortality. It occurs when donor T lymphocyte react to foreign host cells. The physiopathology is a more complex process implicating host tissues damage caused by the conditioning regimen, cytokines ...
V, Moalic, C, Ferec
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Graft vs host disease is a serious immunological complication of allogeneic haematopoietic cell transplantation, leading to a significant morbidity and mortality. It occurs when donor T lymphocyte react to foreign host cells. The physiopathology is a more complex process implicating host tissues damage caused by the conditioning regimen, cytokines ...
V, Moalic, C, Ferec
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Approaches to graft‐vs‐host disease
Pediatric Transplantation, 2005Abstract: Graft‐vs‐host disease (GVHD) is one of the most difficult problems in stem cell transplantation. It is best considered in the context of the normal immune response. The role of the immune system is to identify and eliminate foreign antigens.
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Biology of Graft-vs.-Host Disease
Journal of Pediatric Hematology/Oncology, 1993Graft-vs.-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation, which is an important approach for the treatment of various diseases. In experimental animal models, lethal GVHD can be induced in major histocompatibility complex (MHC)-matched strain combinations that differ in their expression of multiple minor ...
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Skin Changes in Graft-vs-Host Disease
Southern Medical Journal, 1976In this review of the clinical and histopathologic manifestations of the graft-vs-host reaction, the characteristic changes in the skin are given particular emphasis, since they are among the earliest and most obvious signs of this syndrome. The acute and chronic forms of graft-vs-host disease are distinguished, with notation of their different ...
R L, Spielvogel, S, Ullman, R W, Goltz
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2004
Transplantation immunobiology: thymic T-cell development MHC class 1: structure and function MHC class II: structure and function biological inhibitors of lymphocyte coreceptors for antigen-specific immunosuppression immunosuppression andimmunophilin ligands: cyclosporin A, FK506, and rapamycin leucocyte adhesion, trafficking, and migration cytokine ...
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Transplantation immunobiology: thymic T-cell development MHC class 1: structure and function MHC class II: structure and function biological inhibitors of lymphocyte coreceptors for antigen-specific immunosuppression immunosuppression andimmunophilin ligands: cyclosporin A, FK506, and rapamycin leucocyte adhesion, trafficking, and migration cytokine ...
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Graft–Vs.–Host Disease After Liver Transplantation
Hepatology, 1990Clinically evident, generalized graft–vs.–host disease is not thought to occur as a consequence of transplantation of most solid organs. The large inoculum of donor lymphoid cells required and the inability of the recipient to destroy these passenger cells are apparently rarely produced by solid–organ transplantation. However,
G, Alexander, B, Portmann
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