Results 201 to 210 of about 99,620 (352)

Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective

The FEBS Journal, EarlyView.
Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska, Anna Koczurowska, Marta Orlikowska, Maciej Nielipinski, Dominika Nielipinska, Bartosz Sekula   +5 more
wiley   +1 more source

The State of Antimicrobial Resistance of Gram-Negative Bacilli in Canada. [PDF]

Trop Med Infect Dis
Li J, Walkty A, Lagacé-Wiens P, Karlowsky J, Zhanel G.   +4 more
europepmc   +1 more source

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

The FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima, Dev Sriranganadane, Daiane Laise da Silva, Natália C. Drebes Dörr, Enzo Breviglieri Sichi Mello, Caio Vinicius dos Reis, Rogério Ferreira Lourenço, José Felipe Teixeira da Silva Santos, Anita Salmazo, Brenno Wendler Miranda, Katlin B. Massirer, Rafael M. Couñago, Cristina E. Alvarez‐Martinez   +12 more
wiley   +1 more source

Evaluation of risk factors and outcome of patients with polymyxin-resistant critical pathogens gram-negative bacilli in Hospital Kuala Lumpur. [PDF]

J Pharm Policy Pract
Ambaras Khan R, Woh Yon M, Ramadas A, Yee TS, Sheng Teck VO, Makhtar SNA, Yee Shan C, Chee Loon L, Che Husin NS, Khalid KE, Hashim R, Ismail I.   +11 more
europepmc   +1 more source

Meropenem‐Heparin Lock Therapy for Ochrobactrum intermedium Catheter‐Related Bloodstream Infection in a Pediatric Hemodialysis Patient: A Case Report and Literature Review

Hemodialysis International, EarlyView.
ABSTRACT Background In pediatric hemodialysis patients with exhausted vascular access, managing rare pathogens like Ochrobactrum intermedium is challenging, often posing a dilemma between catheter removal and salvage attempts. There are few reports on the supported viability of meropenem‐heparin lock therapy for this purpose in pediatric patients. Case
Mônica Cristina Dutra Rodrigues, Fernanda Teixeira Sillva, Anderson Pereira de Oliveira, Yeo Jim Kinoshita Moon, Jhohann Richard de Lima Benzi   +4 more
wiley   +1 more source

Efficacy of Continuous vs. Intermittent Administration of Cefepime in Adult ICU Patients with Gram‐Negative Bacilli Bacteremia: A Randomized Double‐Blind Clinical Study

Carlos Álvarez, Laura Cristina Nócua-Báez, Guillermo Ortíz, Juan Carlos Torres, Gabriel Montenegro, Williams Cervera, Alonso Gómez, Luis Fernando Zuluaga   +7 more
openalex   +2 more sources

Non fermentative gram negative bacilli as nosocomial pathogens: Identification and antibiotic sensitivity in clinical samples of indoor patients

, 2015
D.P. Sharma, Nitya Vyas, Parul Sinha, Anmol Mathur   +3 more
openalex   +2 more sources

Bacterial porphyrins in healthy skin: Microbiota components impact melanogenesis and age‐related processes leading to Porphyr'ageing

International Journal of Cosmetic Science, EarlyView.
Porphyrins, previously linked only to acne inflammation, are now implicated in skin ageing. Their presence correlates with increased melanin, inflammation, and oxidative stress, contributing to premature ageing signs. This study introduces the concept of “Porphyr'ageing,” highlighting the detrimental effects of bacterial metabolites on skin health and ...
Marie Meunier, Morgane De Tollenaere, Cyrille Jarrin, Emilie Chapuis, Marine Bracq, Laura Lapierre, Catherine Zanchetta, Jean Tiguemounine, Amandine Scandolera, Romain Reynaud   +9 more
wiley   +1 more source

A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations

International Journal of Cosmetic Science, EarlyView.
Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos, Newton Andréo‐Filho, Patricia Santos Lopes, Vânia Rodrigues Leite‐Silva   +3 more
wiley   +1 more source

Phenotype Detection and Drug Resistance Analysis of Carbapenem-Resistant Gram-Negative Bacilli. [PDF]

J Clin Lab Anal
Liu XM, Wu YX, Li XH, Shang JW, Xu WN, Xu NS, Zeng QY, Zheng X.   +7 more
europepmc   +1 more source