Results 151 to 160 of about 430,389 (345)

Beta-Lactams Dosing in Critically Ill Patients with Gram-Negative Bacterial Infections: A PK/PD Approach [PDF]

, 2021
Kelly Maguigan, Mohammad H. Al‐Shaer, Charles A. Peloquin   +2 more
openalex   +1 more source

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Hybrids of copper cysteamine nanosheets and silver nanocluster ensure superior bactericidal capability via enhanced photodynamic effect

Scientific Reports
Over the past decades, bacterial infections resulting from the misuse of antibiotics have garnered significant attention. Among the alternative antibacterial strategies, photodynamic therapy (PDT) has emerged as a promising non-antibiotic approach ...
Jie Wang, Dong Chen, Kaitong Yang, Chenglong Song, Wenzhao Chen, Peng Chang, Danfeng Shen, Zhiqiang Zhu   +7 more
doaj   +1 more source

Detection of Extended Spectrum Beta-lactamase Gene (CTX-M) among Representative Multidrug-Resistant Gram-negative Bacterial Isolates from Patients with Urinary Tract Infections

, 2021
Ayodele Oluwaseun Ajayi, Samuel A. Osanyinlusi, Oluwabukola Atinuke Popoola, Bryan Ogeneh   +3 more
openalex   +1 more source

Genetically‐Programmed Hypervesiculation of Lactiplantibacillus Plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model

Advanced Science, EarlyView.
The development of a novel engineered strain of Lactiplantibacillus plantarum (Lp) is reported that can produce bacterial extracellular vesicles (BEVs) at >60‐fold higher yields than the unmodified parental strain. These Lp BEVs retain therapeutic bioactivity as validated in a mouse model of dextran sodium sulfate‐induced colitis.
Nicholas H Pirolli, Daniel Levy, Alyssa Schledwitz, Natalia Sampaio Moura, Mitali Sarkar, Talia J. Solomon, Emily H. Powsner, Raith Nowak, Zuzanna Mamczarz, Christopher J. Bridgeman, Sulayman Khan, Andrew Hui, Nidhi Anne, Laura Reus, William E. Bentley, Jean‐Pierre Raufman, Steven M. Jay   +16 more
wiley   +1 more source

Visible Light‐Activated ZnO@CuO Coaxial Nanofibers Enhance Infected Skin Wound Healing Through Construction of p‐n Heterojunctions

Advanced Science, EarlyView.
Coaxial ZnO@CuO nanofibers activated by visible light generate ROS through enhanced photocatalytic reactions driven by improved electron hole separation in the heterojunction. This strategy enables rapid antimicrobial activity and early infection control, thereby promoting the healing of MRSA infected and diabetic wounds with biosafe and easily ...
Pengrui Dang, Han Zhao, Chenguang Zhang, Jiechen Wang, Fangyu Zhu, Qinqiu Zhong, Wenyi Zeng, Xinyuan Wang, Yumin Chen, Xu Yan, Xuliang Deng, Wenwen Liu   +11 more
wiley   +1 more source

Real-World Experience with Ceftolozane-Tazobactam for Multidrug-Resistant Gram-Negative Bacterial Infections [PDF]

, 2020
Sarah C J Jorgensen, Trang D Trinh, Evan J Zasowski, Abdalhamid M Lagnf, Samuel Simon, Sahil Bhatia, Sarah Melvin, Molly E. Steed, Natalie A. Finch, Taylor Morrisette, Sandy Estrada, Joshua Rosenberg, Susan L. Davis, Michael J. Rybak   +13 more
openalex   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

OCULAR INFECTIONS: RATIONAL APPROACH TO ANTIBIOTIC THERAPY

National Journal of Medical Research, 2012
Background: Isolation of common pathogens involved in ocular infection and their in-vitro susceptibility to commonly used ocular antibiotics, as well as the trends in antibiotic resistance developed by these pathogens were investigated.
Mulla Summaiya A, Khokhar Neeta D, Revdiwala Sangita B   +2 more
doaj